INT216110

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 3.24
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
body 1
AAVS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 22 88.64 High High
Inflammation 15 77.40 Quite High
anesthesia 7 72.84 Quite High
Osteoarthritis 5 72.52 Quite High
ketamine 6 70.24 Quite High
Pyramidal cell 57 44.96 Quite Low
nMDA receptor 72 43.16 Quite Low
rheumatoid arthritis 15 38.28 Quite Low
antagonist 8 35.28 Quite Low
Inflammatory response 6 28.60 Quite Low
Disease Link Frequency Relevance Heat
Immunization 2 100.00 Very High Very High Very High
Disease 68 99.44 Very High Very High Very High
Factor Ix Deficiency 2 99.32 Very High Very High Very High
Body Weight 7 99.10 Very High Very High Very High
Coagulation Disorder 4 93.40 High High
Infection 50 92.24 High High
Sarcoglycanopathies 4 91.12 High High
Arthritis 20 88.64 High High
Cytomegalovirus Infection 63 84.08 Quite High
Colorblindness 1 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first step toward achieving our goal was to test AAV1, AAV6 and AAV8 under identical conditions, an experiment not previously done, to establish which serotype is most likely to be successful in a regional vascular delivery clinical trial.
AAV Binding (test) of
1) Confidence 0.36 Published 2007 Journal J Transl Med Section Body Doc Link PMC2082019 Disease Relevance 0.14 Pain Relevance 0
AAV2 has not been associated with a human disease.
AAV Binding (associated) of associated with disease
2) Confidence 0.36 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.32 Pain Relevance 0
The PCR product was digested with NotI and ligated to the NotI fragment of pAAVLacZ (Stratagene) containing the AAV2 ITRs, creating pAAVTGFP.
AAV Binding (ligated) of
3) Confidence 0.36 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0.06 Pain Relevance 0
The resulting fragment was cut with BsiWI and SwaI, and ligated into the corresponding sites of pAAVRC to make pAAVRCKI.
AAV Binding (ligated) of
4) Confidence 0.36 Published 2009 Journal Virol J Section Body Doc Link PMC2687429 Disease Relevance 0 Pain Relevance 0
The two helper plasmids, pAAV-RC and pHelper (Agilent Technologies, Santa Clara, California), harbor the AAV rep and cap genes, and the E2A, E4, and VA RNA genes of the adenovirus genome, respectively.
AAV Binding (harbor) of
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.24 Pain Relevance 0.04
Adeno-associated virus (AAV) vectors
AAV Binding (Adeno-associated virus) of
6) Confidence 0.15 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.07 Pain Relevance 0
The primary receptors required for transduction for some of these AAV serotypes have been identified (such as sialic acid for AAV4 and AAV5 (Kaludov et al 2001; Walters et al 2001), including the sialo-glycoprotein PDGF-R (Di Pasquale et al 2003)) and can thus be associated with the transduction pattern for the relevant AAV.
AAV Binding (associated) of
7) Confidence 0.14 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0 Pain Relevance 0
In nature the helper is often adenovirus, and AAV was first isolated in association with adenovirus, hence its name.
AAV Binding (association) of
8) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.39 Pain Relevance 0.15
Haemophilia B patients receiving intramuscular injections of AAV encoding FIX were shown to have consistent local expression of FIX up to 3.7 years following delivery [11].
AAV Binding (injections) of associated with factor ix deficiency
9) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.38 Pain Relevance 0
This could be relevant considering that ongoing human trials with proof-of-principle intramuscular injections can produce life-long immunization against AAV.
AAV Binding (immunization) of associated with immunization
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.72 Pain Relevance 0
There are some recognized drawbacks to the current AAV vectors.
AAV Binding (recognized) of
11) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2743804 Disease Relevance 0.39 Pain Relevance 0
Of note, microgliosis was observed to be intense, and spatially and temporally closely associated with AAV-Tau induced degenerating neurons [30].
AAV Binding (associated) of in neurons
12) Confidence 0.05 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.13 Pain Relevance 0
Food intake and body weight were measured daily for two weeks following AAV microinjection, and were analyzed beginning on day 4 to allow time for postoperative recovery and for adenoviral gene to be expressed.
AAV Spec (analyzed) Binding (microinjection) of in body associated with body weight
13) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.26 Pain Relevance 0.11
In contrast, lentiviral (LV) vector capsids have a larger physical size (about 100 nm) and are capable of packaging promoter/transgene sequences over twice that of AAV [9].
AAV Binding (packaging) of
14) Confidence 0.02 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0.09 Pain Relevance 0

General Comments

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