INT216120

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.05
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SMO) plasma membrane (SMO) cilium (SMO)
cytoplasm (SMO) signal transducer activity (SMO)
SMO (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 72.00 Quite High
Neuropathic pain 1 67.12 Quite High
melanocortin 1 receptor 2 64.96 Quite High
cryotherapy 18 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 1 97.92 Very High Very High Very High
Stomach Cancer 1 97.04 Very High Very High Very High
Cancer 27 96.84 Very High Very High Very High
Basal Cell Nevus Syndrome 4 95.04 Very High Very High Very High
Syndrome 10 92.64 High High
Skin Cancer 122 90.32 High High
Schizophrenia 1 83.16 Quite High
Metastasis 5 82.56 Quite High
Leukemia 1 82.08 Quite High
Disease 7 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTCH gene is the human homologue of the drosophilia patched gene, negatively regulating Hedgehog signalling via inhibition of Smoothened (Smo), a transmembrane protein.
Negative_regulation (inhibition) of Smo
1) Confidence 0.49 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989864 Disease Relevance 1.01 Pain Relevance 0.06
PTCH gene is the human homologue of the drosophilia patched gene, negatively regulating Hedgehog signalling via inhibition of Smoothened (Smo), a transmembrane protein.
Negative_regulation (inhibition) of Smoothened
2) Confidence 0.49 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989864 Disease Relevance 1.01 Pain Relevance 0.06
It has also been reported that cyclopamine as SMO inhibitor is a potential "mechanism-based" therapeutic agent for the treatment of these tumours[27,28].
Negative_regulation (inhibitor) of SMO associated with cancer
3) Confidence 0.32 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC2082046 Disease Relevance 1.02 Pain Relevance 0.14

General Comments

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