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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.96
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd68) plasma membrane (Cd68) lysosome (Cd68)
Anatomy Link Frequency
histiocytes 1
Cd68 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 50 99.58 Very High Very High Very High
B1 receptor 68 99.36 Very High Very High Very High
Hippocampus 22 97.48 Very High Very High Very High
antidepressant 24 95.44 Very High Very High Very High
cytokine 64 95.36 Very High Very High Very High
Inflammation 48 94.96 High High
depression 90 77.96 Quite High
Central nervous system 14 73.00 Quite High
Bioavailability 2 62.84 Quite High
Eae 12 45.92 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 94.96 High High
Injury 6 92.20 High High
Disease 8 89.16 High High
Reprotox - General 1 11 89.04 High High
Lymphatic System Cancer 1 82.80 Quite High
Hyperplasia 14 78.80 Quite High
Pseudolymphoma 1 78.28 Quite High
Depression 108 77.96 Quite High
Urological Neuroanatomy 2 77.08 Quite High
Seminoma 1 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of relevance, systemic treatment with the selective non-peptide B1 receptor antagonist SSR240612 virtually abolished the CD-68 immunopositivity, but notably this parameter was not significantly altered by imipramine.
Negative_regulation (abolished) of CD-68 associated with antagonist and b1 receptor
1) Confidence 0.41 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.60 Pain Relevance 0.64
The histiocytes stained positive for CD68, S100 by immunohistochemistry and negative for CD1a, while ultrastructural examination confirmed emperipolesis [25].
Negative_regulation (positive) of CD68 in histiocytes
2) Confidence 0.27 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2082069 Disease Relevance 1.16 Pain Relevance 0.08
Of relevance, CD68 labeling was almost completely inhibited in animals pre-treated with the selective kinin B1 receptor antagonist SSR240612 (5 mg/kg, i.p.), but not by the antidepressant drug imipramine (10 mg/kg, i.p.), both given 30 min before LPS.
Negative_regulation (inhibited) of CD68 associated with antidepressant, antagonist and b1 receptor
3) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.20 Pain Relevance 0.77

General Comments

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