INT216124

Context Info Confidence 0.13 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.06 Pain Relevance 0.19

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna) transcription factor binding (Pcna) cytoplasm (Pcna)

Anatomy Link Frequency HPAC 1 BxPC-3 1 lungs 1 Pcna (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 28 73.36 fibrosis 4 49.24 cva 3 15.56 neuralgia 2 5.00 Pain 2 5.00 colic 2 5.00 Rheumatism 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Cancer 90 93.72 Reprotox - General 1 11 91.12 Granuloma 4 85.88 Apoptosis 65 75.76 Death 32 74.56 INFLAMMATION 24 73.36 Disease 10 69.60 Fungal Infection 1 68.48 Brucella Infection 1 66.92 Mycobacterial Infection 1 66.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).

Negative_regulation (decreased) of cyclin in lungs

1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0

This lesion is secondary to a mononuclear decrease in cyclin–guanine monophosphate that impairs the killing of bacteria.

Negative_regulation (decrease) of cyclin

2) Confidence 0.10 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2082069 Disease Relevance 1.45 Pain Relevance 0.16

Also, Cyclin A and Cdk 6 expression levels were decreased in HPAC.

Negative_regulation (decreased) of Cyclin in HPAC

3) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.55 Pain Relevance 0.03

More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.

Negative_regulation (inhibitors) of Cyclin in BxPC-3

4) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.05 Pain Relevance 0

General Comments

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