INT216124

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.06
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pcna) intracellular (Pcna) DNA binding (Pcna)
transcription factor binding (Pcna) cytoplasm (Pcna)
Anatomy Link Frequency
HPAC 1
BxPC-3 1
lungs 1
Pcna (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 28 73.36 Quite High
fibrosis 4 49.24 Quite Low
cva 3 15.56 Low Low
neuralgia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
colic 2 5.00 Very Low Very Low Very Low
Rheumatism 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 90 93.72 High High
Reprotox - General 1 11 91.12 High High
Granuloma 4 85.88 High High
Apoptosis 65 75.76 Quite High
Death 32 74.56 Quite High
INFLAMMATION 24 73.36 Quite High
Disease 10 69.60 Quite High
Fungal Infection 1 68.48 Quite High
Brucella Infection 1 66.92 Quite High
Mycobacterial Infection 1 66.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).
Negative_regulation (decreased) of cyclin in lungs
1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
This lesion is secondary to a mononuclear decrease in cyclin–guanine monophosphate that impairs the killing of bacteria.
Negative_regulation (decrease) of cyclin
2) Confidence 0.10 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2082069 Disease Relevance 1.45 Pain Relevance 0.16
Also, Cyclin A and Cdk 6 expression levels were decreased in HPAC.
Negative_regulation (decreased) of Cyclin in HPAC
3) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.55 Pain Relevance 0.03
More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.
Negative_regulation (inhibitors) of Cyclin in BxPC-3
4) Confidence 0.01 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.05 Pain Relevance 0

General Comments

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