INT21613

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Context Info
Confidence 0.68
First Reported 1981
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 9.05
Pain Relevance 6.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Anatomy Link Frequency
muscle 2
macrophages 1
monocyte 1
brain 1
acinar cells 1
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 20 99.88 Very High Very High Very High
methotrexate 3 99.88 Very High Very High Very High
Glutamate receptor 5 99.72 Very High Very High Very High
rheumatoid arthritis 3 99.28 Very High Very High Very High
cINOD 44 98.72 Very High Very High Very High
Dismenorea 2 98.56 Very High Very High Very High
corticosteroid 61 98.52 Very High Very High Very High
Inflammation 87 98.36 Very High Very High Very High
IPN 2 98.36 Very High Very High Very High
Inflammatory mediators 8 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4 99.28 Very High Very High Very High
Nociception 24 99.16 Very High Very High Very High
Injury 30 98.80 Very High Very High Very High
Dysmenorrhea 2 98.56 Very High Very High Very High
INFLAMMATION 126 98.36 Very High Very High Very High
Inflammatory Pain 2 98.36 Very High Very High Very High
Pancreatic Cancer 8 98.32 Very High Very High Very High
Pancreatitis 77 97.60 Very High Very High Very High
Infection 18 97.56 Very High Very High Very High
Stress 12 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bejar et al. found a high rate of phospholipase A2 production by Bacteroides sp., anaerobic streptococci, Fusobacterium sp., and G. vaginalis.
Gene_expression (production) of phospholipase A2
1) Confidence 0.68 Published 1990 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 2178562 Disease Relevance 0.81 Pain Relevance 0.16
From these results, it is suggested that the analgesic effect of EB-382 in inflammation is exerted through its direct peripheral action, and inhibition of prostaglandin biosynthesis via phospholipase A2, rather than cyclooxygenase.
Gene_expression (biosynthesis) of phospholipase A2 associated with inflammation and analgesic
2) Confidence 0.64 Published 1989 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2787705 Disease Relevance 0.30 Pain Relevance 0.52
Phospholipase A2 is an enzyme which is produced in acinar cells, and persists even in regressive states of chronic pancreatitis, when the production of other enzymes diminishes.
Gene_expression (produced) of Phospholipase A2 in acinar cells associated with chronic pancreatitis
3) Confidence 0.54 Published 1989 Journal Klin. Wochenschr. Section Abstract Doc Link 2648057 Disease Relevance 0.62 Pain Relevance 0.10
These results show that MiDCA1 is a new presynaptic phospholipase A2 that produces neuromuscular blockade in vertebrate nerve-muscle preparations.
Gene_expression (produces) of phospholipase A2 in muscle
4) Confidence 0.42 Published 2005 Journal Toxicon Section Abstract Doc Link 16198388 Disease Relevance 0.06 Pain Relevance 0.21
These results show that MiDCA1 is a new presynaptic phospholipase A2 that produces neuromuscular blockade in vertebrate nerve-muscle preparations.
Gene_expression (produces) of phospholipase A2 in muscle
5) Confidence 0.37 Published 2005 Journal Toxicon Section Abstract Doc Link 16198388 Disease Relevance 0.06 Pain Relevance 0.21
This effect may be of importance in inflammatory pain in that the effect of algogens (including histamine) is enhanced by an increased phospholipase A2-mediated synthesis of prostaglandins.
Gene_expression (synthesis) of phospholipase A2 associated with ipn
6) Confidence 0.35 Published 1981 Journal Agents Actions Section Abstract Doc Link 6122358 Disease Relevance 0.41 Pain Relevance 0.57
The current knowledge of glucocorticoid interference with phospholipase A2 and cyclooxygenase expression is summarized.
Gene_expression (expression) of phospholipase A2
7) Confidence 0.31 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9260864 Disease Relevance 0.26 Pain Relevance 0.26
We found that COX-2-/- mice have altered expression and activity of enzymes in the AA metabolism cascade, including increases in COX-1, cytosolic phospholipase A2 (cPLA2) and secretory phospholipase A2 expression [5].
Gene_expression (expression) of phospholipase A2
8) Confidence 0.21 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.10
The selective inhibitors of phospholipase A2, 4-bromophenacyl bromide (300 µM), and of cyclooxygenase, indomethacin (10 µM), prevented the swelling of Müller cells from Dp71-null mice (Fig. 5C; 103.3±2.1%, n?
Gene_expression (selective) of phospholipase A2 associated with pressure and volume under development
9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.81 Pain Relevance 0.30
The lack of sPLA2IB, sPLA2IIA, and sPLA2V mRNA expression in both NIH3T3 and MC3T3E1 cells suggests that cPLA2 is the most likely enzyme that catalyzes the release of AA, the rate-limiting substrate of COX for the production of PGs.
Gene_expression (expression) of sPLA2IB
10) Confidence 0.20 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.19 Pain Relevance 0.54
Clearly, this was not mediated by increased expression of COX and most likely, therefore, was due to increased expression of phospholipase A2 (19), the enzyme responsible for liberation of the substrate arachidonic acid.
Gene_expression (expression) of phospholipase A2
11) Confidence 0.19 Published 2008 Journal FASEB J Section Body Doc Link PMC2691413 Disease Relevance 0.35 Pain Relevance 0.57
We found that COX-2-/- mice have altered expression and activity of enzymes in the AA metabolism cascade, including increases in COX-1, cytosolic phospholipase A2 (cPLA2) and secretory phospholipase A2 expression [5].
Gene_expression (expression) of phospholipase A2
12) Confidence 0.18 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.07 Pain Relevance 0.11
Similar alterations have been observed in COX-1-/- mice, in which COX-2 protein expression and cPLA2 and secretory phospholipase A2 gene and protein expression are increased [6].
Gene_expression (expression) of phospholipase A2 gene
13) Confidence 0.18 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.06 Pain Relevance 0.10
Our results suggest that: (a) sPLA2IB receptor-mediated COX-2 expression is mediated via C/EBPbeta; (b) NSAIDs in the presence of sPLA2IB potentiate the stimulatory effects of sPLA2IB on COX-2 mRNA expression; and (c) despite the apparent stimulation of COX-2 expression by NSAIDs, they strikingly deprive COX-2 of its substrate, AA, by suppressing cPLA2 mRNA expression.
Gene_expression (expression) of sPLA2IB associated with cinod
14) Confidence 0.16 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10706128 Disease Relevance 0.14 Pain Relevance 0.43
The first step in PG biosynthesis involves the conversion of glycerophospholipid into free AA by phospholipase A2, which is ubiquitously present in all brain tissues and whose expression is upregulated by infection or injury [167].
Gene_expression (present) of phospholipase A2 in brain associated with injury and infection
15) Confidence 0.13 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.41 Pain Relevance 0.16
Serum phospholipase A2 activity in patients with rheumatoid arthritis before and after treatment with methotrexate, auranofin, or combination of the two.
Gene_expression (activity) of phospholipase A2 associated with rheumatoid arthritis and methotrexate
16) Confidence 0.11 Published 1996 Journal J. Rheumatol. Section Title Doc Link 8882023 Disease Relevance 0.28 Pain Relevance 0.34
Activation of the N-methyl-D-aspartate (NMDA) receptor results in a calcium-dependent production of nitric oxide, while activation of alpha-amino-3-hydroxy-5-methylisoxazole-5-propionate (AMPA)-and 1,3- trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD)-sensitive glutamate receptors results in a phospholipase A2 (PLA2)-mediated production of different intracellular mediators, including arachidonic acid.
Gene_expression (production) of phospholipase A2 associated with glutamate receptor
17) Confidence 0.10 Published 1994 Journal Drugs Section Abstract Doc Link 7525181 Disease Relevance 0.34 Pain Relevance 0.60
AA is produced from membrane phospholipids by phospholipase A2 (PLA2), a calcium-dependent enzyme, which is activated by proinflammatory agents and shear stress exerted on the vessel wall.
Gene_expression (produced) of phospholipase A2 associated with stress
18) Confidence 0.09 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.20 Pain Relevance 0.10
This study suggested that the inhibitory effect of resveratrol involves inhibition of the p38 mitogen activated protein kinase (MAPK), cytosolic phospholipase A2 (cPLA2), arachidonic acid (AA), thromboxane A2 (TxA2), intracellular calcium concentration [Ca2+]i cascade, and activation of nitric oxide (NO)/cyclic guanosine monophosphate (GMP), resulting in inhibition of phospholipase C (PLC) and/or protein kinase C (PKC) activation, thereby leading to inhibition of [Ca2+]i or free radical formation, and finally inhibition of platelet aggregation (Shen et al 2007).
Gene_expression (cytosolic) of phospholipase A2 in platelet associated with kinase c
19) Confidence 0.08 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.36 Pain Relevance 0.16
Lysophosphatidic acid is also produced in a spatially regulated fashion by the Ca2+-independent phospholipase A2 (iPLA2) at the leading edge of the migrating monocyte (Carnevale and Cathcart, 2001; Mishra et al., 2008).
Gene_expression (produced) of phospholipase A2 in monocyte
20) Confidence 0.07 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0.04

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