INT216144

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.59
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MIR21 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 98.16 Very High Very High Very High
agonist 4 96.68 Very High Very High Very High
Bile 1 66.48 Quite High
Inflammation 67 63.60 Quite High
Inflammatory response 11 60.32 Quite High
Central nervous system 55 42.28 Quite Low
Inflammatory stimuli 3 26.96 Quite Low
tolerance 10 21.68 Low Low
addiction 4 8.12 Low Low
Multiple sclerosis 316 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 8 99.34 Very High Very High Very High
Cancer 317 99.04 Very High Very High Very High
Necrosis 5 83.04 Quite High
Carcinoma 9 81.04 Quite High
Apoptosis 47 76.12 Quite High
Death 18 75.24 Quite High
INFLAMMATION 85 63.60 Quite High
Breast Cancer 11 61.84 Quite High
Autoimmune Disease 92 60.96 Quite High
Lymphatic System Cancer 7 57.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, miR-21 is upregulated in all it's associated cancer types (except Hematologic) and shows a strong oncogenic characteristic.
Positive_regulation (upregulated) of miR-21 associated with cancer
1) Confidence 0.19 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.13 Pain Relevance 0.03
The potential arsenic biomarker set is composed of transcripts for the CXL1, DUSP1, EGR-1, IER2, JUNB, MIRN21, OSM, PTGS2, RNF149, SFRS5, and SOC3 genes (Table 1).
Positive_regulation (composed) of MIRN21
2) Confidence 0.16 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0 Pain Relevance 0
In a study by Chan et al., miRNA expression analysis of human glioblastoma tumor tissues, early-passage glioblastoma cultures, and six established glioblastoma cell lines displayed strikingly elevated miR-21 levels when compared to controls [60].
Positive_regulation (elevated) of miR-21 associated with cancer and glioblastoma
3) Confidence 0.08 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.86 Pain Relevance 0
-UTR of Foxp3 mRNA whereas miR-21 acts as a positive, though indirect, regulator of Foxp3 expression [117].
Positive_regulation (acts) of miR-21
4) Confidence 0.05 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0 Pain Relevance 0
MiR-146, miR-147, and miR-21 are also upregulated after the activation of TLR4 upon stimulation via LPS [150–152].
Positive_regulation (upregulated) of miR-21
5) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.60 Pain Relevance 0.16

General Comments

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