INT216249

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF492) intracellular (ZNF492) DNA binding (ZNF492)
Anatomy Link Frequency
ventricle 1
ZNF492 (Homo sapiens)
ZNF492 - F1473C (1)
Pain Link Frequency Relevance Heat
Action potential 14 96.60 Very High Very High Very High
Mexiletine 21 94.96 High High
addiction 7 74.76 Quite High
potassium channel 5 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
action potential duration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 13 5.00 Very Low Very Low Very Low
Sudden Infant Death Syndrome 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Syncope 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 3 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 2 5.00 Very Low Very Low Very Low
Sudden Death 2 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Channelopathies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 7 summarizes experiments designed to detect whether or not the F1473C mutation augments inward Na+ channel current under conditions that are similar to repolarization of the ventricle, and further, whether or not mexiletine and ranolazine are effective inhibitors of this current using previously-described negative ramp voltage protocols (Methods)[19].
Neg (not) Spec (whether) Positive_regulation (augments) of F1473C (F1473C) in ventricle associated with mexiletine
1) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.24

General Comments

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