INT21625

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Context Info
Confidence 0.40
First Reported 1985
Last Reported 1993
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.40
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Anatomy Link Frequency
blood 2
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
peptic ulcer disease 2 100.00 Very High Very High Very High
cINOD 8 99.30 Very High Very High Very High
lidocaine 9 98.88 Very High Very High Very High
abdominal pain 1 90.48 High High
alcohol 1 88.40 High High
aspirin 1 68.36 Quite High
withdrawal 1 55.76 Quite High
Disease Link Frequency Relevance Heat
Disease 3 100.00 Very High Very High Very High
Ulcers 10 99.98 Very High Very High Very High
Abdominal Pain 1 90.48 High High
Constipation 1 89.76 High High
Gastroesophageal Reflux Disease 1 89.12 High High
Diarrhoea 1 87.12 High High
Injury 4 84.96 Quite High
Recurrence 3 83.80 Quite High
Peptic Ulcer 1 80.08 Quite High
Anaemia 6 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quality of healing in peptic ulcer disease--are H2 receptor antagonists all we need?
Negative_regulation (disease--are) of Gene_expression (antagonists) of H2 receptor associated with antagonist, peptic ulcer disease and disease
1) Confidence 0.40 Published 1993 Journal Gastroenterol. Jpn. Section Title Doc Link 8103021 Disease Relevance 0.98 Pain Relevance 0.27
The absence of ranitidine effects on the disposition of lidocaine, a high-extraction, high-clearance drug, suggests that H2-receptor blockade may not decrease hepatic blood flow, and that cimetidine impairs drug elimination only by inhibition of hepatic microsomal enzymes.
Neg (not) Spec (may) Negative_regulation (decrease) of Gene_expression (blockade) of H2-receptor in blood associated with lidocaine
2) Confidence 0.39 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 3987178 Disease Relevance 0 Pain Relevance 0.60
ITF 282 resulted, also when administered together with H2-receptor antagonists, in the expected therapeutic efficacy, with the expected clinical tolerability and biological safety, without signs of possible interaction, negative or positive.
Spec (possible) Negative_regulation (administered) of Gene_expression (antagonists) of H2-receptor associated with antagonist
3) Confidence 0.24 Published 1993 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 8100220 Disease Relevance 0.74 Pain Relevance 0.18
Drugs often used in the treatment of NSAID-associated mucosal damage include H2-receptor blockers, which inhibit gastric acid secretion, and agents such as synthetic prostaglandins and sucralfate, which improve mucosal defense.
Negative_regulation (inhibit) of Gene_expression (blockers) of H2-receptor associated with cinod
4) Confidence 0.03 Published 1990 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 2181675 Disease Relevance 0.68 Pain Relevance 0.83

General Comments

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