INT216250

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 0.98
Pain Relevance 0.88

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nucleus (ZNF492) intracellular (ZNF492) DNA binding (ZNF492)
ZNF492 (Homo sapiens)
ZNF492 - F1473C (10)
Pain Link Frequency Relevance Heat
Mexiletine 210 99.92 Very High Very High Very High
action potential duration 20 99.36 Very High Very High Very High
addiction 70 99.32 Very High Very High Very High
Action potential 140 83.20 Quite High
potassium channel 50 80.28 Quite High
lidocaine 40 29.12 Quite Low
sodium channel 30 6.56 Low Low
Disease Link Frequency Relevance Heat
Disease 50 95.28 Very High Very High Very High
Syndrome 130 84.52 Quite High
Heart Rate Under Development 30 79.24 Quite High
Arrhythmia Under Development 20 61.84 Quite High
Sudden Death 20 56.64 Quite High
Syncope 40 55.96 Quite High
Sudden Infant Death Syndrome 60 5.00 Very Low Very Low Very Low
Repression 10 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 10 5.00 Very Low Very Low Very Low
Channelopathies 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 2A and B compare averaged raw TTX-sensitive current traces recorded in HEK 293 cells expressing WT (A) and F1473C mutant (B) Na+ channels at sufficiently low gain to capture peak Na+ channel currents.
Gene_expression (expressing) of F1473C (F1473C)
1) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.13 Pain Relevance 0
10 mV in cells expressing WT and F1473C (arrow) channels.
Gene_expression (expressing) of F1473C (F1473C)
2) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.09 Pain Relevance 0
Impact</span> of ionic and genetic background on phenotype of F1473C carriers: insight from computational modeling
Gene_expression (carriers) of F1473C (F1473C)
3) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.31 Pain Relevance 0.11
As shown in the figure, the F1473C mutation causes almost a +10mV depolarizing shift in the V1/2 of channel availability (WT: V1/2?
Gene_expression (mutation) of F1473C (F1473C)
4) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.07 Pain Relevance 0.06
Figures 6B and 6C reveal that, at concentrations that significantly inhibit INaL (Figure 5), both ranolazine (50 µM) and mexiletine (50 µM ranolazine) cause similar and significant hyperpolarizing shifts in the voltage-dependence of steady-state inactivation for F1473C channels (Mexiletine: ?
Gene_expression (channels) of F1473C (F1473C) associated with addiction and mexiletine
5) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.25
Biophysical Consequences of the F1473C mutation: multiple mechanisms contribute to delayed repolarization
Gene_expression (mutation) of F1473C (F1473C)
6) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.25 Pain Relevance 0.04
Computational modeling: dramatic effects of the F1473C mutation on ventricular action potential duration and restoration of wild type cellular phenotype by Na+ channel blockers
Gene_expression (mutation) of F1473C (F1473C) associated with action potential duration
7) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.18
Figure 2D, which presents summary data, shows that the F1473C mutation causes a 6-fold increase in non-inactivating late current (INaL) measured at 200ms during pulses to ?
Gene_expression (mutation) of F1473C (F1473C)
8) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.08 Pain Relevance 0.04
0.3 and F1473C: k?
Gene_expression (0.3) of F1473C (F1473C)
9) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.05 Pain Relevance 0.15
In the experiments illustrated in Figure 4C, positive voltage ramps (Methods) were imposed on HEK 293 cells expressing WT and F1473C channels (see labels in figure), in the absence and presence of TTX.
Gene_expression (expressing) of F1473C (F1473C)
10) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.05

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