INT216252

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF492) intracellular (ZNF492) DNA binding (ZNF492)
ZNF492 (Homo sapiens)
ZNF492 - F1473C (2)
Pain Link Frequency Relevance Heat
Mexiletine 42 99.92 Very High Very High Very High
addiction 14 99.66 Very High Very High Very High
Action potential 28 24.80 Low Low
potassium channel 10 9.08 Low Low
lidocaine 8 5.00 Very Low Very Low Very Low
sodium channel 6 5.00 Very Low Very Low Very Low
action potential duration 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 10 75.12 Quite High
Syndrome 26 13.32 Low Low
Sudden Infant Death Syndrome 12 5.00 Very Low Very Low Very Low
Syncope 8 5.00 Very Low Very Low Very Low
Heart Rate Under Development 6 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 4 5.00 Very Low Very Low Very Low
Sudden Death 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Channelopathies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure</span> 2D, which presents summary data, shows that the F1473C mutation causes a 6-fold increase in non-inactivating late current (INaL) measured at 200ms during pulses to ?
Positive_regulation (causes) of Gene_expression (mutation) of F1473C (F1473C)
1) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0.08 Pain Relevance 0.04
Figures 6B and 6C reveal that, at concentrations that significantly inhibit INaL (Figure 5), both ranolazine (50 µM) and mexiletine (50 µM ranolazine) cause similar and significant hyperpolarizing shifts in the voltage-dependence of steady-state inactivation for F1473C channels (Mexiletine: ?
Positive_regulation (inactivation) of Gene_expression (channels) of F1473C (F1473C) associated with addiction and mexiletine
2) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.26

General Comments

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