INT216261

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.12
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cacna1c) nucleus (Cacna1c) transmembrane transport (Cacna1c)
cytoplasm (Cacna1c)
Anatomy Link Frequency
plasma 2
cardiomyocytes 2
Cacna1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 91.68 High High
cva 2 76.40 Quite High
metalloproteinase 4 50.16 Quite High
depression 4 46.68 Quite Low
fibrosis 20 28.92 Quite Low
headache 8 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 2 93.84 High High
Coronary Heart Disease 18 93.24 High High
Appetite Loss 2 92.64 High High
Alcohol Addiction 2 91.52 High High
Syndrome 2 89.76 High High
Hypertrophy 12 88.00 High High
Pernicious Anemia 2 79.04 Quite High
Hemorrhage 2 76.40 Quite High
Reticulocytosis 2 75.12 Quite High
Myocardial Infarction 5 69.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1A-AR-AB to neonatal cardiomyocytes affected intracellular Ca2+ at two different levels, namely the acute, short-term elevation of intracellular Ca2+, and the increased transcript expression of Cacna1c [5].
Regulation (affected) of Gene_expression (expression) of Cacna1c in cardiomyocytes
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.53 Pain Relevance 0.11
Table 7 shows the predictors of abnormal RBC cholinesterase levels and abnormal MCV as dependent variables.
Regulation (abnormal) of Gene_expression (levels) of RBC
2) Confidence 0.09 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0 Pain Relevance 0
In addition, certain conditions other than pesticide exposure can lower plasma and RBC cholinesterase levels, confounding interpretation of test results.
Regulation (lower) of Gene_expression (levels) of RBC in plasma
3) Confidence 0.09 Published 2007 Journal J Occup Med Toxicol Section Body Doc Link PMC2089062 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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