INT216290

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BTK) cytosol (BTK) plasma membrane (BTK)
nucleus (BTK) cytoplasm (BTK)
Anatomy Link Frequency
B cells 2
BTK (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 92 96.96 Very High Very High Very High
Disease 2 86.40 High High
Immunodeficiency 10 73.04 Quite High
Infection 12 62.40 Quite High
Pneumonia 8 50.00 Quite Low
Cytomegalovirus Infection 2 30.40 Quite Low
Togavirus Infection 2 29.52 Quite Low
Measles 2 28.96 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 17.68 Low Low
Liver Failure 2 12.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This deletion places a stop codon just downstream, thus producing a truncated BTK protein with 604 amino acid residues instead of the normal BTK protein with 659 residues (Fig. 1C,D).
Positive_regulation (truncated) of Gene_expression (producing) of BTK
1) Confidence 0.48 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.53 Pain Relevance 0
Monocytes with deleted BTK are not representative of all that is happening in the B cells, despite the fact that the detection of the BTK production in monocytes by flow cytometry is a powerful diagnostic tool for screening XLA patients.
Positive_regulation (detection) of Gene_expression (production) of BTK in B cells associated with agammaglobulinemia
2) Confidence 0.48 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.95 Pain Relevance 0

General Comments

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