INT216291

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.90
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BTK) cytosol (BTK) plasma membrane (BTK)
nucleus (BTK) cytoplasm (BTK)
Anatomy Link Frequency
T cell 1
BTK (Homo sapiens)
Pain Link Frequency Relevance Heat
Leflunomide 15 85.68 High High
Arthritis 20 81.20 Quite High
corticosteroid 3 75.68 Quite High
methotrexate 14 67.08 Quite High
cINOD 4 56.28 Quite High
Angina 2 9.16 Low Low
rheumatoid arthritis 81 5.00 Very Low Very Low Very Low
Osteoarthritis 32 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Agammaglobulinemia 218 100.00 Very High Very High Very High
Immunodeficiency 24 99.78 Very High Very High Very High
Viral Meningitis 10 97.88 Very High Very High Very High
Infection 60 96.80 Very High Very High Very High
Bacterial Infection 16 95.44 Very High Very High Very High
Polio 6 91.68 High High
Disease 65 91.60 High High
Otitis Media 18 87.44 High High
Giardiasis 2 86.28 High High
Diarrhoea 2 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients on TNF inhibitors (Enbrel or Humira) exhibited significant reductions in levels of p-AKT, p-BTK, p-ERK, p-JNK, p-p38, p-PLC?
Negative_regulation (reductions) of BTK
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.06 Pain Relevance 0.45
The patient showed a partial BTK deficiency, and his mother showed a two-peak BTK expression profile.
Spec (partial) Negative_regulation (deficiency) of BTK
2) Confidence 0.41 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.60 Pain Relevance 0
X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency caused by disruption of the Bruton's tyrosine kinase (BTK) gene.
Negative_regulation (disruption) of BTK associated with agammaglobulinemia and immunodeficiency
3) Confidence 0.41 Published 2001 Journal Respir Res Section Abstract Doc Link PMC2092384 Disease Relevance 0.94 Pain Relevance 0
This phenomenon might be explained by the fact that T cell function in XLA is not impaired, so partial immune defense mechanisms can compensate for impaired humoral immunity.
Negative_regulation (impaired) of XLA in T cell associated with agammaglobulinemia
4) Confidence 0.10 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 1.36 Pain Relevance 0.07
All of these episodes could lead to a differential diagnosis including XLA.19
Negative_regulation (diagnosis) of XLA associated with agammaglobulinemia
5) Confidence 0.07 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615253 Disease Relevance 1.94 Pain Relevance 0.14

General Comments

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