INT21632

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Context Info
Confidence 0.70
First Reported 1980
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 15.67
Pain Relevance 11.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
plasma 12
liver 3
renal tubules 1
chest 1
proximal 1
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Buprenorphine 34 100.00 Very High Very High Very High
Clonidine 27 100.00 Very High Very High Very High
Catecholamine 8 99.68 Very High Very High Very High
Morphine 15 99.52 Very High Very High Very High
anesthesia 26 99.04 Very High Very High Very High
Pain 5 98.92 Very High Very High Very High
opiate 8 98.68 Very High Very High Very High
epidural 8 98.60 Very High Very High Very High
carbamazepine 9 98.32 Very High Very High Very High
halothane 4 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 26 100.00 Very High Very High Very High
Natriuresis 34 99.52 Very High Very High Very High
Hyponatremia 36 99.42 Very High Very High Very High
Pressure Volume 2 Under Development 17 99.12 Very High Very High Very High
Pain 5 98.92 Very High Very High Very High
Respiratory Syncytial Virus 218 98.72 Very High Very High Very High
Stress 28 98.68 Very High Very High Very High
Sprains And Strains 3 98.38 Very High Very High Very High
Injury 58 98.24 Very High Very High Very High
Hypoxia 16 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidiuretic agents, especially those which potentiate ADH activity, may also have marked effects on lithium clearance.
Positive_regulation (potentiate) of ADH
1) Confidence 0.70 Published 1990 Journal Kidney Int. Suppl. Section Abstract Doc Link 2182927 Disease Relevance 0 Pain Relevance 0.10
We found that chronic morphine administration, at doses sufficient to markedly depress serum testosterone levels (> 85%), produced large increases in liver ADH activity and the clearance of ethanol.
Positive_regulation (increases) of ADH in liver associated with morphine
2) Confidence 0.69 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7003096 Disease Relevance 0 Pain Relevance 0.42
Moreover, when increases in liver ADH activity and the metabolism of ethanol were allowed to develop to maximal levels (2 weeks), a single s.c. injection of testosterone promptly reversed the effects of castration, such that by 24 hr castrated animals were indistinguishable from controls.
Positive_regulation (increases) of ADH in liver
3) Confidence 0.69 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7003096 Disease Relevance 0 Pain Relevance 0.16
These findings suggest that the increases in ADH and PRA are due to the compensatory effects related to both diuresis and the long-lasting hypotensive effect induced by high plasma concentrations of clonidine.
Positive_regulation (increases) of ADH in plasma associated with diuresis, hypotension and clonidine
4) Confidence 0.66 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8900500 Disease Relevance 0.55 Pain Relevance 1.15
In contrast, in the two groups of patients receiving extradural morphine a delayed and stepwise increase in plasma ADH concentration was documented.
Positive_regulation (increase) of ADH in plasma associated with morphine
5) Confidence 0.57 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.66
The main factors that elevate plasma ADH level during surgery were pain at the skin incision, the manipulation of the pleura and vagotomy.
Positive_regulation (elevate) of ADH in plasma associated with pain
6) Confidence 0.57 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.26 Pain Relevance 0.39
Elevation of plasma ADH level was not a primary factor of oliguiria during and just after surgery.
Positive_regulation (Elevation) of ADH in plasma
7) Confidence 0.57 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.22 Pain Relevance 0.31
Experimental conditions which produce high levels of endogenous ADH or potentiate the action of endogenous ADH may also adversely effect FeLi as a quantitative marker for proximal delivery.
Positive_regulation (levels) of ADH in proximal
8) Confidence 0.50 Published 1990 Journal Kidney Int. Suppl. Section Abstract Doc Link 2182927 Disease Relevance 0 Pain Relevance 0.08
This is caused mainly by fluid overload due to excesssive drinking and a release of ADH induced by hypovolemia and stress which impairs the excretion of free water.
Positive_regulation (induced) of ADH
9) Confidence 0.46 Published 2007 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 17726655 Disease Relevance 0.05 Pain Relevance 0
Pentobarbital produced slight elevations of ADH activities in vitro and phenobarbital had no effects.
Positive_regulation (elevations) of ADH
10) Confidence 0.43 Published 1985 Journal Pharmacology Section Abstract Doc Link 3160048 Disease Relevance 0 Pain Relevance 0.35
These high levels of ADH were sometimes, but not invariably, accompanied by a fall in arterial pressure.
Positive_regulation (levels) of ADH
11) Confidence 0.43 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7400713 Disease Relevance 0.42 Pain Relevance 0.10
Transient high levels of ADH were seen in animals which were exposed to hypoxia during halothane or pentobarbitone anaesthesia.
Positive_regulation (levels) of ADH associated with hypoxia and halothane
12) Confidence 0.43 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7400713 Disease Relevance 0.44 Pain Relevance 0.10
Base-line plasma ADH was 5.1 +/- 0.9 mu/ml, remained unchanged at 15 min after clonidine injection but increased to 21.6 +/- 7.2 muU/ml by 60 min and was accompanied by an increase in urinary ADH excretion from 19.6 +/- 3.7 to 48.6 +/- 5.3 muU/hr.
Positive_regulation (increased) of ADH in plasma associated with clonidine
13) Confidence 0.41 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.85 Pain Relevance 0.88
ADH, cortisol and epinephrine concentrations showed slight elevations during and after the operation.
Positive_regulation (elevations) of ADH
14) Confidence 0.40 Published 1993 Journal Masui Section Abstract Doc Link 8366567 Disease Relevance 0.16 Pain Relevance 0.40
The drug entrapment efficiency decreased (90-86%) with increasing concentration of ADH (2-6% w/v) in the gelation medium.
Positive_regulation (increasing) of ADH
15) Confidence 0.40 Published 2009 Journal Pharm Dev Technol Section Abstract Doc Link 19235554 Disease Relevance 0.07 Pain Relevance 0
Therefore, patients who received the larger dose of buprenorphine had better control of hemodynamics and catecholamines, but a greater elevation of plasma ADH levels.
Positive_regulation (elevation) of ADH in plasma associated with catecholamine and buprenorphine
16) Confidence 0.39 Published 1989 Journal J Cardiothorac Anesth Section Abstract Doc Link 2520912 Disease Relevance 0.07 Pain Relevance 1.27
The purpose of this study is to analyze the causes of elevation of plasma antidiuretic hormone (ADH) level during surgery and the relationship between urinary volume and plasma ADH level by measuring plasma ADH level of patients undergoing operation for esophageal cancer.
Spec (analyze) Positive_regulation (elevation) of ADH in plasma associated with esophageal cancer
17) Confidence 0.38 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.22 Pain Relevance 0.25
Elevation of the plasma ADH level was partially suppressed by epidural analgesia combined with GOF anesthesia.
Positive_regulation (Elevation) of ADH in plasma associated with anesthesia, epidural and analgesia
18) Confidence 0.38 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785129 Disease Relevance 0.25 Pain Relevance 0.38
At any case, more studies are needed to ascertain whether the current management of ADH might be modified.
Positive_regulation (management) of ADH associated with hyperplasia
19) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1885798 Disease Relevance 1.18 Pain Relevance 0
However, in contrast to plasma catecholamines, the antidiuretic hormone (ADH) levels in the B12 group remained higher until the first postoperative day.
Positive_regulation (higher) of ADH in B12 associated with catecholamine and buprenorphine
20) Confidence 0.28 Published 1989 Journal J Cardiothorac Anesth Section Abstract Doc Link 2520912 Disease Relevance 0.18 Pain Relevance 1.50

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