INT216361

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
Muscle 2
oligodendrocytes 2
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 14 98.62 Very High Very High Very High
psoriasis 2 66.44 Quite High
spinal inflammation 1 65.88 Quite High
chemokine 4 34.24 Quite Low
Spinal cord 1 22.24 Low Low
cva 51 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 87 99.60 Very High Very High Very High
Apoptosis 3 81.56 Quite High
Disease 10 81.28 Quite High
Psoriasis 2 66.44 Quite High
Ankylosing Spondylitis 1 65.88 Quite High
Autoimmune Disease 4 64.64 Quite High
Neurodegenerative Disease 8 36.40 Quite Low
Recurrence 1 17.92 Low Low
Asthma 44 6.04 Low Low
Cv General 4 Under Development 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Distribution of Immunoreactive MBP and Smooth Muscle Actin in Human Airway Bronchus following Overnight Incubation with Human Eosinophils
Negative_regulation (following) of Gene_expression (Distribution) of MBP in Muscle
1) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Specifically, the relative area of PGP 9.5 positive and MBP positive was 7.0 ± 3.0 percent compared to PGP 9.5 negative and MBP positive 5.9 ± 1.3 percent, (P > .7, n = 3 determinations from 10 distinct patients).
Negative_regulation (positive) of Gene_expression (positive) of MBP
2) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0 Pain Relevance 0
Expression of MBP for oligodendrocytes was found in control primary MSCs but an increase in its expression was found following the bFGF treatment, and in B10 cells MBP expression was demonstrated only after the bFGF treatment.
Negative_regulation (demonstrated) of Gene_expression (expression) of MBP in oligodendrocytes
3) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0
regulator are present in MS CNS and that the LMP2 60HH genotype impinges upon MS, likely in part by reducing the production of a specific HLA-A*02 restricted Myelin Basic Protein epitope (MBP111–119) implicated in MS pathology [13], [14], [15] as shown in in vitro assays and in the presence of PA28-??.
Negative_regulation (reducing) of Gene_expression (production) of Basic Protein epitope associated with multiple sclerosis and central nervous system
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.90 Pain Relevance 0.19

General Comments

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