INT216365

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.27
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP2) peptidase activity (CASP2) mitochondrion (CASP2)
aging (CASP2) nucleus (CASP2) intracellular (CASP2)
Anatomy Link Frequency
Mouse 1
brain 1
corpus callosum 1
hippocampus 1
neural 1
CASP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 300 100.00 Very High Very High Very High
Hippocampus 60 99.92 Very High Very High Very High
cytokine 21 94.12 High High
Inflammation 9 93.72 High High
Neurotransmitter 48 91.52 High High
ketamine 6 86.80 High High
antagonist 6 86.16 High High
gABA 12 85.12 High High
Paracetamol 12 68.48 Quite High
addiction 6 67.08 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 246 100.00 Very High Very High Very High
Death 7 97.76 Very High Very High Very High
Hematoma 12 96.24 Very High Very High Very High
INFLAMMATION 14 93.72 High High
Stroke 132 92.64 High High
Apoptosis 3 90.52 High High
Cv General 3 Under Development 54 89.28 High High
Osteoarthritis 23 50.00 Quite Low
Pain 51 24.64 Low Low
Disease 23 9.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All investigators were informed of ICH-GCP guidelines.
Gene_expression (informed) of ICH
1) Confidence 0.65 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2131759 Disease Relevance 0.09 Pain Relevance 0.34
Expression data was available for the following Bcl-2 genes: Bcl-2, Bfl-1 (BCL2A1), Bik, Bcl-w (BCL2L2), Bax, BCLAF1 (Bcl2-associated transcription factor 1); and for the following caspase genes: Caspase-1, Caspase-2, Caspase-3, Caspase-6, Caspase-8, Caspase-9, Caspase-10.
Gene_expression (genes) of Caspase-2
2) Confidence 0.18 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2791157 Disease Relevance 0.32 Pain Relevance 0
Transplanted B10 cells in ICH brain express neural cell-specific markers
Gene_expression (brain) of ICH in neural associated with cva
3) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.75 Pain Relevance 0.37
B10 cells migrate to hemorrhagic lesion, corpus callosum and hippocampus in ICH model
Gene_expression (model) of ICH in hippocampus associated with cva and hippocampus
4) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.62 Pain Relevance 0.66
Mouse ICH model
Gene_expression (model) of ICH in Mouse associated with cva
5) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.20 Pain Relevance 0.27
Recovery of behavioral deficits in ICH model by B10 cell transplantation
Gene_expression (model) of ICH associated with cva
6) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.43 Pain Relevance 0.30
We also examined the levels of human BDNF in ICH brain sections 2, 4 and 6 weeks post-transplantation (Figure 11C).
Gene_expression (sections) of ICH in brain associated with cva
7) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.24 Pain Relevance 0.15
B10 cells migrate to hemorrhagic lesion, corpus callosum and hippocampus in ICH model
Gene_expression (model) of ICH in corpus callosum associated with cva and hippocampus
8) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.62 Pain Relevance 0.66

General Comments

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