INT216371

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.12
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2)
cytoplasm (MAP2)
Anatomy Link Frequency
neuronal 4
MAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 99.66 Very High Very High Very High
gABA 6 99.52 Very High Very High Very High
Dopamine 85 98.72 Very High Very High Very High
midbrain 20 98.60 Very High Very High Very High
Neuritis 2 70.32 Quite High
Spinal cord 3 39.36 Quite Low
Glutamate 9 24.72 Low Low
cva 50 5.00 Very Low Very Low Very Low
Neurotransmitter 15 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuritis 2 70.32 Quite High
Neurodegenerative Disease 23 53.52 Quite High
Spinal Cord Injury 1 34.68 Quite Low
Disease 6 33.28 Quite Low
Brain Injury 4 28.00 Quite Low
Injury 5 11.68 Low Low
Epilepsy 1 7.28 Low Low
Stroke 23 6.88 Low Low
Adhesions 2 6.16 Low Low
Cv General 4 Under Development 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetical analysis also showed increased expression of additional neuronal cell type-specific markers, synaptophysin and MAP2.
Positive_regulation (increased) of Gene_expression (expression) of MAP2 in neuronal
1) Confidence 0.22 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.05 Pain Relevance 0
Western blot analysis confirmed expression of the MAP2, Nuclear receptor 1 (Nurr1), and TH proteins (Fig. 5B).
Positive_regulation (confirmed) of Gene_expression (expression) of MAP2
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.28
Induced cells with Neuronal Progenitor Basal Medium (NPBM medium) or Neurobasal added with a mix cytokines, demonstrate an increased expression of Tyrosine Hydroxylase (TH), MAP-2, NF, NeuN, GABA, nestin and GFAP [14,16].
Positive_regulation (increased) of Gene_expression (expression) of MAP-2 in Neuronal associated with gaba and cytokine
3) Confidence 0.11 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0.17

General Comments

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