INT216372

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.97
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ENPP3)
Anatomy Link Frequency
neurons 3
ENPP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 300 99.72 Very High Very High Very High
Hippocampus 60 98.20 Very High Very High Very High
ischemia 36 89.48 High High
cytokine 18 68.72 Quite High
Neurotransmitter 48 37.72 Quite Low
dexamethasone 18 5.00 Very Low Very Low Very Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
gABA 12 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 246 99.72 Very High Very High Very High
Stroke 132 97.56 Very High Very High Very High
Neurodegenerative Disease 42 95.44 Very High Very High Very High
Middle Cerebral Artery Infarction 6 94.00 High High
Cv Unclassified Under Development 30 89.48 High High
Cv General 3 Under Development 54 76.04 Quite High
Brain Hemorrhage 6 66.40 Quite High
Parkinson's Disease 12 65.44 Quite High
Brain Injury 12 64.48 Quite High
Injury 18 36.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B10 MSCs secrete both NGF and BDNF proteins in higher concentrations in vitro and in vivo than primary human MSCs.
Localization (secrete) of B10
1) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.73 Pain Relevance 0.18
Further studies are needed to determine whether grafted B10 MSCs could integrate among the neurons of host brain, make new synaptic connections with them and replace lost neurons.
Localization (grafted) of B10 in neurons
2) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.61 Pain Relevance 0.13
ELISA analyses indicated that the levels of human BDNF released by B10 cells in vitro were 8.18±0.04 ng/106 cells/day (mean±SEM) in the spent medium of B10 culture of 24 hr, which were five times higher than those from human primary MSCs (1.53±0.31 ng/106 cells/day, p<0.001) (Figure 11A).
Localization (released) of B10
3) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.20 Pain Relevance 0.18
B10 cells secrete 40% higher level of NGF into the culture medium.
Localization (secrete) of B10
4) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.22 Pain Relevance 0.15
A considerable number of the transplanted B10 migrate to the boundary region, corpus callosum and hippocampus in the contralateral side of transplantation and differentiate into neurons even in far beyond hemorrhagic stroke site.
Localization (migrate) of B10 in neurons associated with stroke and hippocampus
5) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.50 Pain Relevance 0.18
In the present study, grafted B10 cells located in peri-hemorrhagic lesion sites express strong BDNF activity, which indicate that the grafted B10 cells secrete BDNF neurotrophic factor in the microenvironment of ICH and promote survival of host neurons and functional recovery of ICH animals.
Localization (secrete) of B10 in neurons associated with cva
6) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.71 Pain Relevance 0.17

General Comments

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