INT216377

Context Info Confidence 0.69 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 0.58 Pain Relevance 0.05

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1) DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)

Anatomy Link Frequency endometrium 2 POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 6 96.72 Inflammation 51 50.00 pain pelvic 4 45.32 Dismenorea 4 42.76 Hippocampus 12 31.48 cva 50 5.00 cytokine 30 5.00 cINOD 9 5.00 Neurotransmitter 8 5.00 ischemia 6 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 11 96.72 Cancer 72 78.96 Colorectal Cancer 2 77.52 Neurodegenerative Disease 7 69.28 Colon Cancer 60 57.36 Keloid Scars 103 50.00 INFLAMMATION 55 50.00 Obesity 10 50.00 Targeted Disruption 2 49.36 Reprotox - General 3 4 45.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The endogenous mRNA expression of Oct3/4, Sox2, Klf4, c-Myc, p53, p21 and Tert in pGFs, mGFs and TTFs at passages 4 to 6 was determined by real-time RT-PCR analysis.

Transcription (expression) of Oct3

1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0

In the present study we assessed the mRNA levels and protein expression of OCT-4 in human endometrium.

Transcription (expression) of OCT-4 in endometrium

2) Confidence 0.69 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0

In ES cells, Oct4 and Sox2 were shown to reciprocally regulate Pou5f1 and Sox2 transcription via the Oct4, Sox2 complex in ES cells [5].

Transcription (transcription) of Pou5f1

3) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0

Expression of Oct3/4 mRNA was not detected in the primary GFs and TTFs.

Transcription (Expression) of Oct3

4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0

Expression of Oct3/4 mRNA was not detected in the primary GFs and TTFs.

Neg (not) Transcription (detected) of Oct3

5) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0

In conclusion, we evaluated the mRNA-transcription and protein expression of the stem cell marker OCT-4 in human endometrium and found that OCT-4 is frequently expressed in human endometrium, but is not involved in menstrual cycle regulation.

Transcription (transcription) of OCT-4 in endometrium

6) Confidence 0.47 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.10 Pain Relevance 0.05

The 8q24 locus contains two transcripts with open reading frames, which are both mapped to the region of LD at 8q24.21: DQ515897 is a gene with unknown function and DQ486513 is a putative pseudogene of the POU5F1, which encodes the transcription factor OCT4 [29].

Transcription (transcription) of factor OCT4

7) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3017062 Disease Relevance 0.27 Pain Relevance 0

Moreover, proneural genes, Otx-1, Neurogenin 2 and Musashi 1 as well as Oct-4 and nestin have been expressed in mRNA level in human MSCs as reorted earlier in adult derived human MSCs [6].

Transcription (expressed) of Oct-4

8) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.07 Pain Relevance 0

KPCs expressed relatively higher levels of Oct-4, Rex-1, Nanog, and human telomerase reverse transcriptase (hTERT) mRNAs than SKPs (Figure 1F).

Transcription (expressed) of Oct-4

9) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.14 Pain Relevance 0

General Comments

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