INT216379

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.10
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT1) extracellular space (WNT1) extracellular region (WNT1)
proteinaceous extracellular matrix (WNT1) plasma membrane (WNT1) cell-cell signaling (WNT1)
Anatomy Link Frequency
stem cell 2
WNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 2 95.84 Very High Very High Very High
Spinal cord 3 95.00 High High
Neurotransmitter 14 94.20 High High
metalloproteinase 1 87.68 High High
substance P 1 75.60 Quite High
Action potential 2 66.00 Quite High
antagonist 16 45.52 Quite Low
Glutamate receptor 5 22.72 Low Low
agonist 3 10.88 Low Low
Glutamate 6 9.44 Low Low
Disease Link Frequency Relevance Heat
Cancer 71 99.16 Very High Very High Very High
Carcinoma 12 97.52 Very High Very High Very High
Breast Cancer 56 96.52 Very High Very High Very High
Neurodegenerative Disease 16 96.04 Very High Very High Very High
Non-small-cell Lung Cancer 3 95.76 Very High Very High Very High
Hyperplasia 2 95.76 Very High Very High Very High
Lung Cancer 1 95.52 Very High Very High Very High
Adenocarcinoma 2 94.48 High High
Ovarian Cancer 1 94.16 High High
Prostate Cancer 3 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wnt1 expression [42] in both primary MSCs and B10 cells increased markedly after bFGF treatment.
Positive_regulation (increased) of Gene_expression (expression) of Wnt1
1) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.30 Pain Relevance 0.05
Recent studies have revealed that the Wnt-1 overexpression, resulting in an aberrant and stabilized ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Wnt-1
2) Confidence 0.28 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.66 Pain Relevance 0.04
Using similar neurogenic medium (NPMM or Neurobasal), MSC expressed dopaminergic specific genes (En1, En2, LMx1a, Wnt1, Ptx3, and Nuur1 and were positive to GFAP, MAP-2 and NSE but continued to express the neural stem cell marker nestin.
Positive_regulation (positive) of Gene_expression (expressed) of Wnt1 in stem cell
3) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.08 Pain Relevance 0.24
Wnt1 was originally discovered as an oncogene activated by mouse mammary tumor virus (MMTV) [5], and mice engineered to express either Wnt1 or an activated form of ?
Positive_regulation (activated) of Gene_expression (express) of Wnt1 associated with cancer
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.55 Pain Relevance 0
Wnt1 was originally discovered as an oncogene activated by mouse mammary tumor virus (MMTV) [5], and mice engineered to express either Wnt1 or an activated form of ?
Positive_regulation (discovered) of Gene_expression (discovered) of Wnt1 associated with cancer
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.51 Pain Relevance 0

General Comments

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