INT216384

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.84
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ENPP3)
Anatomy Link Frequency
basophils 4
ventral 1
ENPP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.26 Very High Very High Very High
Kinase C 68 97.24 Very High Very High Very High
cva 50 5.00 Very Low Very Low Very Low
agonist 28 5.00 Very Low Very Low Very Low
Inflammation 25 5.00 Very Low Very Low Very Low
corticosteroid 13 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
withdrawal 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 99.78 Very High Very High Very High
Hypersensitivity 129 96.60 Very High Very High Very High
Obesity 3 64.12 Quite High
Exanthema 14 62.96 Quite High
Drug Eruptions 7 61.92 Quite High
Staphylococcus Infection 21 36.32 Quite Low
Syndrome 19 34.88 Quite Low
Cicatrix 3 33.04 Quite Low
Adverse Drug Reaction 8 32.80 Quite Low
Anaphylaxis 10 28.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous evidence has reported that CD203c and CD63 upregulation in response to calcium signal by A23187 showed different kinetics [28], an evidence that probably suggests different pathways of calcium involvement in the expression of the two markers [46].
Positive_regulation (upregulation) of CD203c
1) Confidence 0.54 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.19
Our results indicate that the calcium-mediated signaling is essential both for the LAMP-1 CD63 and for the ENPP-3 CD203c upregulation, as A23187-mediated calcium influx stimulate both the expression of basophil activation markers and histamine release (see Figure 7), but on the same time they suggest also that the transduction pathway diverges in two distal branches, one of which (LAMP-1) is sensitive to quercetin and is related to the degranulatory event [47], the other is much more resistant to this inhibition.
Positive_regulation (upregulation) of CD203c in basophil
2) Confidence 0.36 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.08
In our assay system the flavonol proved insensitive to target protein kinase C (PKC), as resulted from the use of PMA as basophil stimulant, thus confirming previous reports [19]: quercetin was unable to inhibit CD63 and CD203c membrane up-regulation in basophils stimulated with phorbol esters and no dissociation between the two markers investigated was actually observed by using PMA [45].
Positive_regulation (up-regulation) of CD203c in basophils associated with kinase c
3) Confidence 0.36 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.27
Our results indicate that the calcium-mediated signaling is essential both for the LAMP-1 CD63 and for the ENPP-3 CD203c upregulation, as A23187-mediated calcium influx stimulate both the expression of basophil activation markers and histamine release (see Figure 7), but on the same time they suggest also that the transduction pathway diverges in two distal branches, one of which (LAMP-1) is sensitive to quercetin and is related to the degranulatory event [47], the other is much more resistant to this inhibition.
Positive_regulation (upregulation) of ENPP-3 in basophil
4) Confidence 0.32 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.08
Radioimmunoassays previously used mainly for the diagnosis of penicillin allergy (including the radioallergosorbent test, RAST) have over the years been replaced with the FEIA assays.16,17 Flow-cytometric based basophil activation tests (BAT) (flow assay stimulation test, FAST/FlowCAST®, Buhlmann Laboratories) which measure CD69 or CD203c on drug-specific activated basophils may have a role in the diagnosis of antibiotic allergy, with studies so far mainly focused on beta-lactam allergy.18
Positive_regulation (measure) of CD203c in basophils associated with hypersensitivity
5) Confidence 0.09 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846744 Disease Relevance 0.54 Pain Relevance 0
Expression levels of Pax3, which is involved in the brain regionalizaion and establishment of dorso-ventral polarity of the spinal cord during early neurogenesis [41] were increased in both primary human MSCs and B10 cells following bFGF treatment of 2 weeks.
Positive_regulation (increased) of B10 in ventral associated with neurodegenerative disease and spinal cord
6) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.30 Pain Relevance 0.05

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