INT216426

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.68
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (UCP2) mitochondrion (UCP2) small molecule metabolic process (UCP2)
Anatomy Link Frequency
beta cell 2
UCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 6 64.32 Quite High
Inflammation 16 61.68 Quite High
agonist 4 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 60 99.80 Very High Very High Very High
Obesity 60 97.04 Very High Very High Very High
Hyperinsulinism 3 84.00 Quite High
Hyperglycemia 21 79.88 Quite High
Diabetes Mellitus 87 72.92 Quite High
INFLAMMATION 17 61.68 Quite High
Death 9 51.96 Quite High
Stress 9 35.44 Quite Low
Diabetes Complications 3 33.60 Quite Low
Insulin Resistance 13 10.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Panax quinquefolius's ability to regulate UCP-2 may explain how it increases beta cell function and viability.


Regulation (regulate) of UCP-2 in beta cell
1) Confidence 0.09 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.60 Pain Relevance 0.03
This indicates that the anti-apoptotic effects of Panax quinquefolius may be achieved through regulating mitochondrial UCP-2 and ATP levels, thereby influencing insulin synthesis and apoptotic cascades in beta cells [17] (Figure 1).
Regulation (regulating) of UCP-2 in beta cells associated with apoptosis
2) Confidence 0.09 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.97 Pain Relevance 0.13
target genes (UCP-2, LPL, p85aPI3K, and PPAR?
Regulation (target) of UCP-2
3) Confidence 0.05 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.32 Pain Relevance 0
By regulating the UCP-2 level, Panax quinquefolius increases ATP production, thereby increasing insulin production, meanwhile it prevents apoptosis by reducing caspase-9 activation and raising levels of Bcl-2 [17].
Regulation (regulating) of UCP-2 associated with apoptosis
4) Confidence 0.04 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.79 Pain Relevance 0.03

General Comments

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