INT216428

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.37
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (UCP2) mitochondrion (UCP2) small molecule metabolic process (UCP2)
Anatomy Link Frequency
telomere 1
UCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 54.64 Quite High
Angina 6 12.08 Low Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 282 99.46 Very High Very High Very High
Stress 104 99.00 Very High Very High Very High
Genetic Predisposition To Disease 6 93.88 High High
Aging 31 93.84 High High
Hyperinsulinism 1 88.00 High High
Apoptosis 23 84.16 Quite High
Atherosclerosis 9 76.96 Quite High
Nicotine Addiction 21 75.64 Quite High
Metabolic Syndrome 15 60.28 Quite High
Death 3 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased UCP2 expression results in increased ROS production, in vitro [19], while animal studies have shown that absence of UCP2 causes higher oxidative stress [20].
Negative_regulation (absence) of UCP2 associated with stress
1) Confidence 0.43 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.91 Pain Relevance 0
Finally, in vitro investigation of the UCP2 down-regulation will establish the role of this gene in determining the intracellular oxygen species levels, the oxidative-induced telomere loss and the consequent cell senescence.


Negative_regulation (regulation) of UCP2 in telomere associated with aging
2) Confidence 0.43 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 1.07 Pain Relevance 0
On the other hand, it is believed that the association of UCP2 with T2D is caused by a pancreatic effect of UCP2 on insulin secretion.
Negative_regulation (effect) of UCP2 associated with diabetes mellitus
3) Confidence 0.42 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.88 Pain Relevance 0
Panax quinquefolius significantly reduces the level of UCP-2 and increases ATP in the mitochondrion.
Negative_regulation (reduces) of UCP-2
4) Confidence 0.06 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

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