INT216430

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (UCP2) mitochondrion (UCP2) small molecule metabolic process (UCP2)
Anatomy Link Frequency
telomere 1
UCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 42.00 Quite Low
Opioid 6 39.84 Quite Low
Angina 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 3 97.20 Very High Very High Very High
Apoptosis 61 96.12 Very High Very High Very High
Stress 40 94.12 High High
Hyperglycemia 21 92.48 High High
Diabetes Mellitus 158 91.44 High High
Metabolic Syndrome 5 76.88 Quite High
Nicotine Addiction 7 76.40 Quite High
Death 9 65.16 Quite High
Diabetes Complications 3 46.80 Quite Low
INFLAMMATION 11 42.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to further enlighten the effect of ROS on telomere shortening, we also studied the effect of uncoupling protein 2 (UCP2) gene variation.
Positive_regulation (uncoupling) of UCP2 in telomere
1) Confidence 0.50 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 1.04 Pain Relevance 0
According to our findings, Panax quinquefolius water extracts reversed an IL-1 beta induced increase of uncoupling protein-2 (UCP-2, a mitochondrial protein which uncouples electron transport from ATP production), decreased pro-apoptotic protein caspase-9 and increased the level of anti-apoptotic protein Bcl-2.
Positive_regulation (increase) of UCP-2 associated with apoptosis
2) Confidence 0.10 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 1.06 Pain Relevance 0
Cells induced with IL-1 beta exhibit a much higher level of UCP-2, indicating that a high level of UCP-2 is harmful to the cell.
Positive_regulation (level) of UCP-2
3) Confidence 0.10 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.52 Pain Relevance 0
Cells induced with IL-1 beta exhibit a much higher level of UCP-2, indicating that a high level of UCP-2 is harmful to the cell.
Positive_regulation (induced) of UCP-2
4) Confidence 0.07 Published 2007 Journal Chin Med Section Body Doc Link PMC2094710 Disease Relevance 0.52 Pain Relevance 0

General Comments

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