INT216452

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lifr) plasma membrane (Lifr)
Anatomy Link Frequency
liver 1
Lifr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 96.40 Very High Very High Very High
Paracetamol 2 64.96 Quite High
Disease Link Frequency Relevance Heat
Aging 126 99.00 Very High Very High Very High
Leukemia 4 91.40 High High
Lifespan 94 89.16 High High
Obesity 2 87.08 High High
Calcification 2 83.72 Quite High
Body Weight 2 81.72 Quite High
Liver Disease 2 79.60 Quite High
Stress 12 75.12 Quite High
Toxicity 2 63.84 Quite High
Sprains And Strains 36 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Determining whether Lifr downregulation in liver contributes to longevity extension represents a difficult task, since Lifr is highly pleiotropic and has been associated with a wide range of biological effects.
Spec (whether) Negative_regulation (downregulation) of Lifr in liver associated with aging
1) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.96 Pain Relevance 0.03
To some degree, inhibition of Lif/Lifr signaling may be countered in long-lived mice by down-regulation of Socs2 (suppressor of cytokine signaling) [47,48], which was also down-regulated in all four long-lived dwarf models.
Negative_regulation (inhibition) of Lifr associated with cytokine
2) Confidence 0.30 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.77 Pain Relevance 0.15

General Comments

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