INT216455

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.71
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lifr) plasma membrane (Lifr)
Anatomy Link Frequency
fat 2
liver 2
Lifr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 96.48 Very High Very High Very High
Paracetamol 2 91.00 High High
Disease Link Frequency Relevance Heat
Aging 126 98.76 Very High Very High Very High
Liver Disease 2 98.32 Very High Very High Very High
Leukemia 4 96.88 Very High Very High Very High
Stress 12 96.08 Very High Very High Very High
Lifespan 94 94.64 High High
Toxicity 2 90.44 High High
Sprains And Strains 36 89.36 High High
Obesity 2 78.76 Quite High
Calcification 2 75.40 Quite High
Body Weight 2 73.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Declines in Lifr expression may increase sensitivity to drug-induced liver disease [49], which in general is contrary to the stress resistance characteristics of long-lived mice [11], but is consistent with one study that found decreased resistance to acetaminophen toxicity in multiple dwarf strains [50].
Negative_regulation (Declines) of Gene_expression (expression) of Lifr in liver associated with stress, liver disease, toxicity, paracetamol and sprains and strains
1) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.83 Pain Relevance 0.17
Lifr expression was downregulated at all ages in four long-lived dwarf models, by short-term CR and by low-fat diet.
Negative_regulation (downregulated) of Gene_expression (expression) of Lifr in fat
2) Confidence 0.36 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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