INT216456

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 4.96
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
plasma 1
diaphragm 1
liver 1
cerebral cortex 1
gastrocnemius 1
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 17 94.20 High High
Eae 9 90.40 High High
Pain 2 84.48 Quite High
tolerance 44 77.28 Quite High
Pyramidal cell 6 72.56 Quite High
Hippocampus 24 54.80 Quite High
midbrain 4 41.76 Quite Low
Thalamus 16 41.20 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 138 98.28 Very High Very High Very High
Body Weight 102 97.68 Very High Very High Very High
Obesity 91 91.24 High High
Anxiety Disorder 16 87.44 High High
Stress 126 84.80 Quite High
Pain 2 84.48 Quite High
Lifespan 89 83.64 Quite High
Impaired Glucose Tolerance 19 77.92 Quite High
Aging 133 74.64 Quite High
Disease 25 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the enhancement of Rd seen in GhrR KO mice was associated with significantly increased glucose uptake in 6 out of 8 tissues tested (WAT, BAT, gastrocnemius, soleus, diaphragm and cerebral cortex; see Figure 4).
Positive_regulation (enhancement) of GhrR in cerebral cortex associated with cerebral cortex
1) Confidence 0.41 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.36 Pain Relevance 0.05
Consistent with this, glucose disposal (Rd) was significantly enhanced in GhrR KO mice (Figure 3B).
Positive_regulation (enhanced) of GhrR
2) Confidence 0.41 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.40 Pain Relevance 0.03
Another possibility is that the difference is due to levels of circulating growth hormone, which is nearly absent in Little mice and elevated in GHR-KO mice [9,15].
Positive_regulation (elevated) of GHR
3) Confidence 0.38 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.23 Pain Relevance 0
These results are consistent with the enhanced insulin sensitivity previously observed in conscious HFD-fed GhrR KO mice [2].
Positive_regulation (enhanced) of GhrR
4) Confidence 0.36 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.35 Pain Relevance 0.11
An increased body weight has been detected in PTPH1-KO mice compared to WT littermates, more pronounced in male mice and probably due to an enhanced GHR sensitivity, that leads to increased IGF-1 mRNA and protein expression in liver and plasma, respectively [22].
Positive_regulation (enhanced) of GHR in plasma associated with targeted disruption and body weight
5) Confidence 0.35 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.22
Regarding gene expression, Al-Regaiey and colleagues (2005) reported an increase of nearly 50% in hepatic mRNA expression of SOD2 in GHR-KO mice presumably mediated via increased FOXO protein and decreased Akt expression.
Positive_regulation (increase) of GHR-KO
6) Confidence 0.21 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.35 Pain Relevance 0
Percentage fat mass, normalized to total body mass, was also elevated in GHR-KO mice over a 2 year period relative to controls, with the increased adiposity more apparent in males [43].
Positive_regulation (elevated) of GHR-KO in body
7) Confidence 0.16 Published 2011 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC3001304 Disease Relevance 1.10 Pain Relevance 0.07
Furthermore, the enhancement of Rd seen in GhrR KO mice was associated with significantly increased glucose uptake in 6 out of 8 tissues tested (WAT, BAT, gastrocnemius, soleus, diaphragm and cerebral cortex; see Figure 4).
Positive_regulation (enhancement) of GhrR in gastrocnemius associated with cerebral cortex
8) Confidence 0.14 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.36 Pain Relevance 0.05
Furthermore, the enhancement of Rd seen in GhrR KO mice was associated with significantly increased glucose uptake in 6 out of 8 tissues tested (WAT, BAT, gastrocnemius, soleus, diaphragm and cerebral cortex; see Figure 4).
Positive_regulation (enhancement) of GhrR in diaphragm associated with cerebral cortex
9) Confidence 0.14 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.36 Pain Relevance 0.05
Furthermore, the enhancement of Rd seen in GhrR KO mice was associated with significantly increased glucose uptake in 6 out of 8 tissues tested (WAT, BAT, gastrocnemius, soleus, diaphragm and cerebral cortex; see Figure 4).
Positive_regulation (enhancement) of GhrR in soleus associated with cerebral cortex
10) Confidence 0.14 Published 2011 Journal BMC Physiol Section Body Doc Link PMC3024223 Disease Relevance 0.36 Pain Relevance 0.05
An increased body weight has been detected in PTPH1-KO mice compared to WT littermates, more pronounced in male mice and probably due to an enhanced GHR sensitivity, that leads to increased IGF-1 mRNA and protein expression in liver and plasma, respectively [22].
Positive_regulation (enhanced) of GHR in liver associated with targeted disruption and body weight
11) Confidence 0.12 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.54 Pain Relevance 0.22

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