INT21647

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 5.54
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 333 100.00 Very High Very High Very High
dexamethasone 5 99.98 Very High Very High Very High
Codeine 4 99.92 Very High Very High Very High
tetrodotoxin 1 99.84 Very High Very High Very High
substance P 3 99.80 Very High Very High Very High
agonist 43 97.60 Very High Very High Very High
antagonist 24 97.60 Very High Very High Very High
B1 receptor 4 97.28 Very High Very High Very High
b2 receptor 9 92.92 High High
Potency 4 92.80 High High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 128 99.92 Very High Very High Very High
Cough 14 99.92 Very High Very High Very High
Pressure And Volume Under Development 30 99.54 Very High Very High Very High
Edema 51 98.76 Very High Very High Very High
Heart Rate Under Development 15 95.24 Very High Very High Very High
Diabetes Mellitus 139 95.04 Very High Very High Very High
Left Ventricular Dysfunction 1 94.28 High High
Wheal 3 92.56 High High
Stress 68 89.84 High High
Targeted Disruption 12 88.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, cromolyn sodium (40 mg dry powder) also significantly reduced response to bradykinin, with a PD35 of 0.04 mumol (range, 0.13 to 0.31) after placebo and 0.39 mumol (range, 0.05 to 4.45) after SCG (p less than 0.05).
Negative_regulation (reduced) of Positive_regulation (response) of bradykinin associated with bradykinin
1) Confidence 0.43 Published 1987 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3541715 Disease Relevance 0.18 Pain Relevance 0.65
However, okadaic acid blocked the bradykinin -evoked increase in resensitization of the second response to ATP (Figures 2A-B).
Negative_regulation (blocked) of Positive_regulation (increase) of bradykinin associated with bradykinin
2) Confidence 0.42 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.49
Studies of the mechanism of angiotensin-converting enzyme (ACE) inhibitor-associated angioedema: the effect of an ACE inhibitor on cutaneous responses to bradykinin, codeine, and histamine.
Negative_regulation (inhibitor) of Positive_regulation (responses) of bradykinin associated with pressure and volume under development, bradykinin and codeine
3) Confidence 0.41 Published 1990 Journal J. Allergy Clin. Immunol. Section Title Doc Link 2185292 Disease Relevance 0.54 Pain Relevance 0.58
The persistence of the bradykinin -induced increase in resensitization of the Ca2+ response to ATP in the absence of extracellular Ca2+ indicates that the entry of calcium through P2X receptors or other Ca2+ influx pathways is not required for the effect of bradykinin on resensitization.
Negative_regulation (persistence) of Positive_regulation (increase) of bradykinin associated with bradykinin
4) Confidence 0.35 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.21 Pain Relevance 0.49
To determine the potential involvement of the PI3K pathway in the resensitization response to bradykinin, we applied the PI3K inhibitor LY294002 (50 ?
Spec (determine) Negative_regulation (determine) of Positive_regulation (response) of bradykinin associated with bradykinin
5) Confidence 0.35 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.44
To determine the potential involvement of the PI3K pathway in the resensitization response to bradykinin, we applied the PI3K inhibitor LY294002 (50 ?
Negative_regulation (resensitization) of Positive_regulation (response) of bradykinin associated with bradykinin
6) Confidence 0.35 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.40
However, the low dose of dexamethasone blunted the vasodilatory response to bradykinin, whereas the high dose (5 mg/kg) was found to enhance the dilatory properties of bradykinin at concentrations of 4 x 10(-3) M.
Negative_regulation (blunted) of Positive_regulation (response) of bradykinin associated with bradykinin and dexamethasone
7) Confidence 0.34 Published 1989 Journal Acta Neuropathol. Section Abstract Doc Link 2750477 Disease Relevance 0 Pain Relevance 0.62
The discovery that bradykinin is primarily responsible for the attacks of swelling in HAE has led to new therapeutic strategies to treat HAE by preventing bradykinin-mediated enhancement in vascular permeability.
Negative_regulation (preventing) of Positive_regulation (enhancement) of bradykinin-mediated associated with hereditary angioedema, edema and bradykinin
8) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 1.00 Pain Relevance 0.31
Relaxation in response to bradykinin (100 nM) was unaffected by tetrodotoxin (0.3 microM), nicardipine (1 microM), Ca(2+)-free solution without or plus ryanodine (10 microM), propranolol (1 microM), glibenclamide (1 microM), staurosporine (0.3 microM), nickel chloride (100 microM) or [D-p-Cl-Phe6,Leu17]VIP (a vasoactive intestinal peptide receptor antagonist, 0.03 microM), but was partially inhibited by apamin (0.3-1 microM).
Neg (unaffected) Negative_regulation (unaffected) of Positive_regulation (response) of bradykinin associated with tetrodotoxin, antagonist and bradykinin
9) Confidence 0.09 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7498273 Disease Relevance 0 Pain Relevance 0.67
It is therefore possible that noscapine suppresses cough by blocking the effect of bradykinin receptor activation in the airways.
Negative_regulation (blocking) of Positive_regulation (activation) of bradykinin associated with cough and bradykinin
10) Confidence 0.08 Published 2003 Journal Acta Physiol Hung Section Abstract Doc Link 12903913 Disease Relevance 0.85 Pain Relevance 0.40
Also, ACE inhibitors are not specific for RAAS, preventing inactivation of bradykinin and substance P that are known to mediate some of the side-effects of ACE inhibitions such as cough and angioedema.
Negative_regulation (preventing) of Positive_regulation (inactivation) of bradykinin associated with pressure and volume under development, cough, bradykinin and substance p
11) Confidence 0.05 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.35 Pain Relevance 0.18
Additionally, inhibition of kallikrein, the activator of high molecular weight kininogen (HMWK) and therefore promotor of bradykinin formation, is a further potential therapeutic alternative.
Negative_regulation (inhibition) of Positive_regulation (activator) of molecular weight kininogen associated with bradykinin
12) Confidence 0.03 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920239 Disease Relevance 0.70 Pain Relevance 0.22
Zhang et al.[130] were able to demonstrate that increased concentrations of Hcy resulted in a decreased NO response to bradykinin and L-arginine.
Neg (NO) Negative_regulation (decreased) of Neg (NO) Positive_regulation (response) of bradykinin associated with bradykinin
13) Confidence 0.03 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.63 Pain Relevance 0.13
The mechanism of action of captopril, an ACEI, involves suppression of angiotensin II, a potent vasoconstrictor, and increased levels of bradykinin through the inhibition of kininase II, which induces NO release in ECs and stimulates the production of prostacyclin, a vasodilating prostaglandin [117].
Negative_regulation (inhibition) of Positive_regulation (increased) of bradykinin associated with bradykinin
14) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.08 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox