INT2165

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Context Info
Confidence 0.80
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 41
Disease Relevance 4.02
Pain Relevance 19.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cga) molecular_function (Cga) cellular_component (Cga)
biological_process (Cga)
Anatomy Link Frequency
pituitary 19
anterior pituitary 13
posterior pituitary 2
follicle 2
tail 1
Cga (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 37 99.92 Very High Very High Very High
Enkephalin 28 99.90 Very High Very High Very High
tail-flick 1 99.80 Very High Very High Very High
Clonidine 10 99.78 Very High Very High Very High
Opioid 26 99.72 Very High Very High Very High
withdrawal 6 99.66 Very High Very High Very High
Buprenorphine 15 99.48 Very High Very High Very High
analgesia 1 99.46 Very High Very High Very High
Morphine 36 99.44 Very High Very High Very High
opiate 46 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 7 99.84 Very High Very High Very High
Fever 1 99.74 Very High Very High Very High
Shock 4 99.68 Very High Very High Very High
Depression 8 99.36 Very High Very High Very High
Cyst 59 97.68 Very High Very High Very High
Headache 15 94.56 High High
Galactorrhea 5 92.12 High High
Stress 8 91.36 High High
Diabetes Insipidus 6 91.32 High High
Body Weight 3 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That is, exposure to either isolation or to shock increased both pituitary-adrenal hormone secretion and tail-flick latencies but only administration of shock potentiated freezing and ultrasonic vocalizations.
Localization (secretion) of pituitary-adrenal hormone in tail associated with shock and tail-flick
1) Confidence 0.80 Published 1991 Journal Dev Psychobiol Section Abstract Doc Link 1661243 Disease Relevance 0.63 Pain Relevance 0.11
The effect of d-fenfluramine on anterior pituitary hormone release in the rat: in vivo and in vitro studies.
Localization (release) of pituitary hormone in anterior pituitary
2) Confidence 0.78 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 3449200 Disease Relevance 0 Pain Relevance 0.25
The peptide injected into the cerebrospinal fluid (CSF) produces a wide spectrum of biological effects including analgesia, hyperthermia, changes in pituitary hormone release, decrease in food and water intake, locomotor activity, and blood pressure.
Localization (release) of pituitary hormone in pituitary associated with eae, fever and analgesia
3) Confidence 0.78 Published 1987 Journal Life Sci. Section Abstract Doc Link 3600197 Disease Relevance 0.44 Pain Relevance 0.36
Although not yet fully established, there is growing evidence that the EOP participate in the physiological regulation of pituitary hormone secretion.
Localization (secretion) of pituitary hormone in pituitary
4) Confidence 0.78 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247213 Disease Relevance 0.08 Pain Relevance 0.73
The opioid peptides have been demonstrated to exert a variety of effects on pituitary hormone secretion in rat and man.
Localization (secretion) of pituitary hormone in pituitary associated with opioid
5) Confidence 0.78 Published 1981 Journal Metab. Clin. Exp. Section Abstract Doc Link 6258010 Disease Relevance 0 Pain Relevance 1.00
The effects of chronic naloxone on pituitary hormone secretion in female rats.
Localization (secretion) of pituitary hormone in pituitary associated with narcan
6) Confidence 0.78 Published 1984 Journal Brain Res. Bull. Section Title Doc Link 6329481 Disease Relevance 0.08 Pain Relevance 0.66
These results indicate that while chronic NAL exposure does not, by itself, persistently alter pituitary hormone secretion, it differentially effects the response of these hormones to morphine exposure.
Localization (secretion) of pituitary hormone in pituitary associated with narcan and morphine
7) Confidence 0.78 Published 1984 Journal Brain Res. Bull. Section Abstract Doc Link 6329481 Disease Relevance 0.09 Pain Relevance 0.66
Role of central epinephrine in regulation of anterior pituitary hormone secretion.
Localization (secretion) of pituitary hormone in anterior pituitary
8) Confidence 0.78 Published 1982 Journal Peptides Section Title Doc Link 6750566 Disease Relevance 0 Pain Relevance 0.19
The effects of neurotensin on anterior pituitary hormone secretion.
Localization (secretion) of pituitary hormone in anterior pituitary
9) Confidence 0.78 Published 1982 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 6820240 Disease Relevance 0 Pain Relevance 0.15
Influence of morphine during pregnancy on neuroendocrine regulation of pituitary hormone secretion.
Localization (secretion) of pituitary hormone in pituitary associated with morphine
10) Confidence 0.78 Published 1983 Journal J. Endocrinol. Section Title Doc Link 6875436 Disease Relevance 0 Pain Relevance 0.72
The administration of morphine or opioid peptides produces alterations in the neuroendocrine regulation of anterior pituitary hormone secretion, including the depression of serum levels of luteinizing hormone (LH).
Localization (secretion) of pituitary hormone in anterior pituitary associated with depression, opioid and morphine
11) Confidence 0.78 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 7022252 Disease Relevance 0.47 Pain Relevance 0.71
The high ratio of expression of NO in magnocellular neurosecretory dynorphin containing neurons suggested that NO participates in controlling posterior pituitary hormone secretion together with dynorphin.
Localization (secretion) of pituitary hormone in posterior pituitary associated with dynorphin
12) Confidence 0.78 Published 1994 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 7528149 Disease Relevance 0 Pain Relevance 0.59
Stimulus-induced depletion of pro-enkephalins, oxytocin and vasopressin and pro-enkephalin interaction with posterior pituitary hormone release in vitro.
Localization (release) of pituitary hormone in posterior pituitary associated with narcan and enkephalin
13) Confidence 0.78 Published 1994 Journal Neuroendocrinology Section Title Doc Link 7700499 Disease Relevance 0.06 Pain Relevance 1.00
It is well established that hypothalamic galanin- and beta-endorphin-containing circuits play important roles in the neuroendocrine regulation of pituitary hormone secretion and sexual behaviors, as well as in feeding.
Localization (secretion) of pituitary hormone in pituitary
14) Confidence 0.78 Published 1995 Journal J. Neuroendocrinol. Section Abstract Doc Link 8704731 Disease Relevance 0 Pain Relevance 0.17
Morphine withdrawal alters anterior pituitary hormone secretion, brain endopeptidase activity and brain monoamine metabolism in the rat.
Localization (secretion) of pituitary hormone in anterior pituitary associated with withdrawal, monoamine and morphine
15) Confidence 0.78 Published 1996 Journal Pharmacol. Toxicol. Section Title Doc Link 8882344 Disease Relevance 0.15 Pain Relevance 0.56
In an attempt to elucidate the effects of norepinephrine on the central control of pituitary hormone secretion, we looked at the actions of norepinephrine on the electrical properties of putative parvocellular neurons of the paraventricular nucleus using whole-cell current-clamp recordings in hypothalamic slices.
Localization (secretion) of pituitary hormone in nucleus
16) Confidence 0.78 Published 2000 Journal Neuroscience Section Abstract Doc Link 10727792 Disease Relevance 0 Pain Relevance 0
Although it has long been known that opioid peptides cause marked changes of pituitary hormone secretion in both animals and humans, little is known about the possible effect(s) of food-derived opioids (exorphins) on pituitary function.
Localization (secretion) of pituitary hormone in pituitary associated with opioid
17) Confidence 0.78 Published 2002 Journal Life Sci. Section Abstract Doc Link 12231399 Disease Relevance 0 Pain Relevance 0.55
These findings support the hypothesis that one site of action of opioid compounds on pituitary hormone secretion is at the level of hypothalamus.
Localization (secretion) of pituitary hormone in pituitary associated with opioid
18) Confidence 0.78 Published 1988 Journal Regul. Pept. Section Abstract Doc Link 3368581 Disease Relevance 0 Pain Relevance 0.81
There are some data suggesting that systemically administered opiates and opioid peptides can act outside of the blood-brain barrier to influence anterior pituitary hormone release.
Localization (release) of pituitary hormone in brain associated with opiate and opioid
19) Confidence 0.78 Published 1987 Journal Psychoneuroendocrinology Section Abstract Doc Link 3035598 Disease Relevance 0 Pain Relevance 0.55
Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone.
Localization (secretion) of pituitary hormone in pituitary associated with neuropeptide
20) Confidence 0.78 Published 1992 Journal Front Neuroendocrinol Section Title Doc Link 1361458 Disease Relevance 0 Pain Relevance 0.10

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