INT21650

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 5.99
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OXTR) signal transducer activity (OXTR)
Anatomy Link Frequency
plasma 8
uterine 5
cerebrospinal fluid 3
smooth muscle 1
pituitary 1
OXTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 26 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
intrathecal 4 100.00 Very High Very High Very High
antagonist 9 99.96 Very High Very High Very High
Endogenous opioid 9 99.68 Very High Very High Very High
narcan 14 99.52 Very High Very High Very High
Opioid 8 99.12 Very High Very High Very High
Dismenorea 29 98.52 Very High Very High Very High
Calcium channel 1 96.60 Very High Very High Very High
agonist 8 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rupture 4 100.00 Very High Very High Very High
Hypoglycemia 15 99.20 Very High Very High Very High
Stress 8 98.84 Very High Very High Very High
Pre-term Labor 10 98.64 Very High Very High Very High
Dysmenorrhea 28 98.52 Very High Very High Very High
Bordatella Infection 17 98.12 Very High Very High Very High
Reprotox - General 2 2 98.08 Very High Very High Very High
Reprotox - General 3 3 93.20 High High
Labor Pain 2 88.40 High High
Lumbar Puncture Related Headaches 6 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of artificial rupture of the membranes on plasma levels of 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and oxytocin was examined in 23 pregnant women at term.
Spec (examined) Regulation (influence) of oxytocin in plasma associated with rupture
1) Confidence 0.61 Published 1983 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6638092 Disease Relevance 0.26 Pain Relevance 0
The influence of oxytocin (OT; an ecbolic agent) and flunixin meglumine (FLU; a prostaglandin inhibitor serving as a model for mares with decreased uterine contractility) on uterine response to artificial insemination (AI) was studied in mares with no history of reproductive failure.
Regulation (influence) of oxytocin in uterine
2) Confidence 0.61 Published 2009 Journal Theriogenology Section Abstract Doc Link 19783032 Disease Relevance 0.10 Pain Relevance 0
Prostaglandins act to mediate cervical ripening and to stimulate uterine contractions and indirectly to increase fundally dominant myometrial contractility by up regulation of gap junctions, oxytocin and arginine vasopressin receptors and synchronizations of contractions.
Regulation (regulation) of oxytocin in uterine associated with dismenorea
3) Confidence 0.61 Published 2001 Journal Coll Antropol Section Abstract Doc Link 11811300 Disease Relevance 0.48 Pain Relevance 0.10
However, different convergent observations on parallel changes in oxytocin levels in plasma and in the brain [20,24,25] would suggest a cooperative process of regulation and, thus, support the use of the peripheral marker as a mirror of the central one [8,26].
Regulation (changes) of oxytocin in brain
4) Confidence 0.58 Published 2006 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1621060 Disease Relevance 0.08 Pain Relevance 0.09
Effects of pregnancy and labor on oxytocin levels in human plasma and cerebrospinal fluid.
Regulation (Effects) of oxytocin in plasma
5) Confidence 0.49 Published 1985 Journal Endocrinol. Jpn. Section Title Doc Link 3833528 Disease Relevance 0.09 Pain Relevance 0.08
These results strongly suggest that oxytocin levels in human plasma and CSF are controlled by different mechanisms and that the increased oxytocin could have some specific central actions.
Regulation (controlled) of oxytocin in CSF
6) Confidence 0.49 Published 1985 Journal Endocrinol. Jpn. Section Abstract Doc Link 3833528 Disease Relevance 0.08 Pain Relevance 0.08
The effect of labour and maternal oxytocin infusion on fetal plasma oxytocin concentration.
Regulation (effect) of oxytocin in plasma
7) Confidence 0.45 Published 1999 Journal Br J Obstet Gynaecol Section Title Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.09
The effect of labour and maternal oxytocin infusion on fetal plasma oxytocin concentration.
Regulation (effect) of oxytocin in plasma
8) Confidence 0.45 Published 1999 Journal Br J Obstet Gynaecol Section Title Doc Link 10609728 Disease Relevance 0 Pain Relevance 0.09
To date, limited data are available on the effects of oxytocin on the regulation of uterine contractility and transport mechanisms in human reproduction.
Regulation (effects) of oxytocin in uterine
9) Confidence 0.42 Published 2006 Journal Eur. J. Med. Res. Section Abstract Doc Link 16720280 Disease Relevance 0 Pain Relevance 0
The goal of this study was to evaluate the effects of oxytocin on uterine contractility and peristalsis in estrogen-primed non-pregnant uteri.
Regulation (effects) of oxytocin in uterine
10) Confidence 0.42 Published 2006 Journal Eur. J. Med. Res. Section Abstract Doc Link 16720280 Disease Relevance 0.05 Pain Relevance 0.05
Our data suggest that two distinct types of G-proteins are involved in the oxytocin response: one most probably a member of the Gq family (pertussis toxin-resistant) and another of the Gi family (pertussis toxin-sensitive).
Regulation (response) of oxytocin associated with bordatella infection
11) Confidence 0.40 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.51 Pain Relevance 0.11
We have measured the effect of oxytocin on the formation of inositol phosphates (InsPs) in cultured human myometrial cells labelled with [3H] inositol and on changes in intracellular free Ca2+ concentration ([Ca2+i]) in single cells using a dynamic calcium imaging system.
Regulation (effect) of oxytocin associated with imagery
12) Confidence 0.40 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.22 Pain Relevance 0.13
Oestrogens exert their effects on the oxytocin pathway at a postreceptor level, possibly by affecting the expression of G-proteins and/or phospholipase C isoforms.
Spec (possibly) Regulation (effects) of oxytocin
13) Confidence 0.40 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.25 Pain Relevance 0.09
Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor.
Regulation (Effects) of plasma oxytocin in plasma associated with intrathecal
14) Confidence 0.39 Published 2001 Journal Reg Anesth Pain Med Section Title Doc Link 11707794 Disease Relevance 0.09 Pain Relevance 0.89
The effect of the opioid antagonist naloxone on the vasopressin and oxytocin responses to insulin-induced hypoglycemia was studied in 14 male subjects.
Regulation (responses) of oxytocin associated with hypoglycemia, antagonist, narcan and opioid
15) Confidence 0.31 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2838996 Disease Relevance 0.23 Pain Relevance 0.49
Pretreatment by SR 49059 caused a dose-related reduction in AUCs for vasopressin, whereas no such effect was seen for oxytocin.
Neg (no) Regulation (effect) of oxytocin
16) Confidence 0.31 Published 2004 Journal Acta Obstet Gynecol Scand Section Body Doc Link 14678081 Disease Relevance 0 Pain Relevance 0
In addition, they strongly suggest a critical role of oxytocin in this process.
Regulation (role) of oxytocin
17) Confidence 0.27 Published 1998 Journal Hum. Reprod. Update Section Abstract Doc Link 10027619 Disease Relevance 0.17 Pain Relevance 0.11
The effectiveness of oxytocin antagonists is not proven.
Regulation (effectiveness) of oxytocin associated with antagonist
18) Confidence 0.25 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.05 Pain Relevance 0.36
Measurements of oxytocin in maternal and fetal circulation during human labor are reviewed and related to known changes in uterine oxytocin sensitivity during pregnancy and labor.
Regulation (sensitivity) of oxytocin in uterine
19) Confidence 0.24 Published 1989 Journal Am J Perinatol Section Abstract Doc Link 2540759 Disease Relevance 0 Pain Relevance 0
The importance of oxytocin and vasopressin in mechanisms of preterm labor is confirmed by the therapeutic effect in the condition of the oxytocin and vasopressin V1a receptor blocking oxytocin analogue, atosiban.
Regulation (importance) of oxytocin associated with pre-term labor
20) Confidence 0.22 Published 2002 Journal Prog. Brain Res. Section Abstract Doc Link 12436949 Disease Relevance 0.55 Pain Relevance 0.22

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