INT216512

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.44
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (C3AR1) signal transducer activity (C3AR1)
Anatomy Link Frequency
cleavage 2
cornea 2
macrophages 1
plasma 1
erythrocytes 1
C3AR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 153 100.00 Very High Very High Very High
cytokine 10 94.00 High High
ischemia 48 89.20 High High
Inflammatory response 75 86.92 High High
Neuropathic pain 27 86.88 High High
Pain 26 85.04 High High
adenocard 1 73.12 Quite High
Peripheral nerve injury 4 58.24 Quite High
spinal dorsal horn 2 52.24 Quite High
Spinal cord 15 51.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 228 100.00 Very High Very High Very High
Atherosclerosis 156 99.60 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 15 99.24 Very High Very High Very High
Age-related Macular Degeneration 195 96.60 Very High Very High Very High
Hemolysis 95 96.00 Very High Very High Very High
Peripheral Arterial Disease 219 90.76 High High
Neurological Disease 1 90.68 High High
Infection 20 89.64 High High
Cerebrovascular Disease 4 89.44 High High
Cv Unclassified Under Development 45 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study shows that C3AR1 and C5R1 are expressed in human atherosclerotic coronary plaques [38].
Gene_expression (expressed) of C3AR1 in plaques associated with atherosclerosis
1) Confidence 0.70 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.20 Pain Relevance 0.04
Double immunofluorescence staining has shown that the plaque of cells that express both C3aR and C5aR are macrophages, T cells, endothelial cells, and sub-endothelial smooth muscle cells.
Gene_expression (express) of C3aR in T cells
2) Confidence 0.70 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.16 Pain Relevance 0.04
Double immunofluorescence staining has shown that the plaque of cells that express both C3aR and C5aR are macrophages, T cells, endothelial cells, and sub-endothelial smooth muscle cells.
Gene_expression (express) of C3aR in endothelial cells
3) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.16 Pain Relevance 0.04
Double immunofluorescence staining has shown that the plaque of cells that express both C3aR and C5aR are macrophages, T cells, endothelial cells, and sub-endothelial smooth muscle cells.
Gene_expression (express) of C3aR in macrophages
4) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 1.16 Pain Relevance 0.04
Similarly activation of complement by dead cells is prevented and maybe therefore the PMN chemotactic factors C3a en C5a will not be produced.
Neg (not) Gene_expression (produced) of C3a
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.33 Pain Relevance 0.21
In these experiments, the normal cornea from human donors was exposed to lipopolysaccharide (LPS), ribitol teichoic acid immune complex, acid (HCl), or alkali (NaOH) separately and the generation of anaphylatoxins—C3a, C4a, and C5a—as well as MAC in the corneas was monitored.
Gene_expression (generation) of C3a in corneas
6) Confidence 0.03 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.25 Pain Relevance 0.04
It was reported that C3a and C5a are present not only in human drusen but are also localized in the choroid of mice with laser-induced CNV [97].
Gene_expression (present) of C3a in choroid associated with ocular toxicity (including many sub-types) and age-related macular degeneration
7) Confidence 0.03 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.71 Pain Relevance 0
The changes in expression of cell-surface molecules (i.e., complement receptor 3, which is recognized by the antibody OX42) and in morphology are widely used as the key diagnostic markers of activated microglia [60, 61].
Gene_expression (expression) of complement receptor 3 in microglia
8) Confidence 0.02 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.07 Pain Relevance 0.57
They observed inhibition of the cleavage of fB to Bb and C3a production when rabbit erythrocytes were used as activators and complete human serum as a source of complement.
Gene_expression (production) of C3a in erythrocytes
9) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
It was reported that anaphylatoxins—C3a, C4a, and C5a—could be generated when the cornea was injured with LPS, immune complexes, acid, or alkali.
Gene_expression (generated) of C3a in cornea
10) Confidence 0.01 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.32 Pain Relevance 0.04
We investigated the effect of I. ricinus IxAC proteins on the cleavage of factor B and on the production of C3a in the AP assay.
Gene_expression (production) of C3a in cleavage
11) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.21 Pain Relevance 0.05
Finally, recombinant Salp20 also inhibits the production of C3a and deposition of C3b on the surface of red blood cells in the AP hemolytic assay [29].
Gene_expression (production) of C3a in red blood cells
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.06 Pain Relevance 0.03
It consists of a cascade of plasma enzymes leading to activation of three effector mechanisms: (i) generation of the short potent pro-inflammatory peptides C3a and C5a, ii) deposition of opsonizing C3b proteins on cell surfaces, (iii) formation of the membrane attack complex (MAC).
Gene_expression (generation) of C3a in plasma associated with inflammation
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.61 Pain Relevance 0.22
The generation of peptide C3a from C3 and the cleavage of factor B in human serum during the AP assay in the presence of I. ricinus IxACs were assessed by western blot analysis as described by Lawrie et al. [39]. 10 µl of supernatant from AP assays conducted in the presence of I. ricinus IxAC or control protein RaHBP2 were analyzed by denaturing SDS/PAGE (C3 cleavage) or by non-denaturating PAGE (fB cleavage).
Spec (analyzed) Gene_expression (generation) of C3a in cleavage
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.18 Pain Relevance 0

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