INT21652

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Context Info
Confidence 0.39
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.16
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreatic islet 2
liver 2
pancreas 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 2 99.90 Very High Very High Very High
Enkephalin 1 98.92 Very High Very High Very High
Chronic pancreatitis 13 98.70 Very High Very High Very High
anesthesia 5 97.32 Very High Very High Very High
adenocard 2 93.92 High High
emotional pain 1 85.56 High High
fibrosis 1 77.28 Quite High
vagus nerve 1 76.16 Quite High
Pain 2 75.00 Quite High
cINOD 1 74.40 Quite High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 2 99.90 Very High Very High Very High
Stress 8 99.84 Very High Very High Very High
Disease 25 99.56 Very High Very High Very High
Diabetes Mellitus 30 99.10 Very High Very High Very High
Pancreatitis 13 98.70 Very High Very High Very High
Insulin Resistance 6 98.60 Very High Very High Very High
Apoptosis 15 94.76 High High
Rheumatoid Arthritis 7 91.08 High High
Pain 2 85.56 High High
Hypoglycemia 1 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the stimulatory effect of insulin is diminished in insulin-resistant patients.
Negative_regulation (diminished) of Negative_regulation (effect) of insulin
1) Confidence 0.39 Published 2008 Journal Metab. Clin. Exp. Section Abstract Doc Link 18940398 Disease Relevance 0.08 Pain Relevance 0.15
Theoretically, thiorphan blocked the catabolism of insulin by inhibiting Enk'ase.
Negative_regulation (blocked) of Negative_regulation (catabolism) of insulin
2) Confidence 0.34 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6383841 Disease Relevance 0.08 Pain Relevance 0.10
Pentobarbital reduces basal liver glucose output and its insulin suppression in rats.
Negative_regulation (reduces) of Negative_regulation (suppression) of insulin in liver
3) Confidence 0.34 Published 1990 Journal Am. J. Physiol. Section Title Doc Link 2185651 Disease Relevance 0.36 Pain Relevance 0.18
Thus, we conclude that the CP model induced by cerulein plus stress is a new CP model with diabetes in rats, in which the glucose tolerance was impaired without loss of insulin reserve.
Negative_regulation (impaired) of Negative_regulation (loss) of insulin associated with stress, diabetes mellitus, tolerance, chronic pancreatitis and impaired glucose tolerance
4) Confidence 0.33 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587814 Disease Relevance 1.34 Pain Relevance 0.73
Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress.
Negative_regulation (inhibits) of Negative_regulation (decrease) of insulin in pancreas associated with stress
5) Confidence 0.27 Published 1990 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 2194205 Disease Relevance 0.51 Pain Relevance 0.16
Immunohistochemical analysis revealed that telmisartan markedly attenuated the reduction in insulin content of pancreatic islet beta-cells, and prevented the indomethacin-induced overexpression of inducible nitric oxide synthase and nuclear factor-kappaB in gastric mucosa of diabetic rats.
Negative_regulation (attenuated) of Negative_regulation (reduction) of insulin in pancreatic islet associated with diabetes mellitus
6) Confidence 0.07 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20399771 Disease Relevance 0.88 Pain Relevance 0.10
In fact, defects in glucose utilization, a striking reduction in insulin receptor mRNA levels, and attenuated insulin signaling, as evidenced by decreased IRS-1, PI3K, and pAKT have been demonstrated in AD [33].
Negative_regulation (defects) of Negative_regulation (reduction) of insulin associated with disease
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.91 Pain Relevance 0.04

General Comments

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