INT216554

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.75
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB6) mitochondrion (ABCB6) Golgi apparatus (ABCB6)
ATPase activity (ABCB6) plasma membrane (ABCB6) transmembrane transport (ABCB6)
Anatomy Link Frequency
astrocytes 1
cavity 1
ABCB6 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 3 94.88 High High
Central nervous system 14 80.96 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
methadone 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 81.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 65 78.84 Quite High
Disorder Of Lipid Metabolism 8 76.08 Quite High
Viral Meningitis 9 71.72 Quite High
Infection 17 62.36 Quite High
Pressure And Volume Under Development 27 54.32 Quite High
Disease 107 52.56 Quite High
Heart Disease 3 52.28 Quite High
Increased Venous Pressure Under Development 24 51.68 Quite High
Lipodystrophy 3 50.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The thymidine analogue mutations (TAMs), which include M41L, D67N, L210W and T215Y/F, K219Q/E/N, are not selected by ABC but rather by the thymidine analogues ZDV and d4T.
Neg (not) Localization (selected) of ABC
1) Confidence 0.28 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.13 Pain Relevance 0
Therefore, ABC transporter
Localization (transporter) of ABC
2) Confidence 0.23 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0.09
Structural model and overall architecture of ABC transporter (CpABC)
Localization (transporter) of ABC
3) Confidence 0.23 Published 2010 Journal Bioinformation Section Body Doc Link PMC2957761 Disease Relevance 0 Pain Relevance 0.09
Recent crystallography studies, consistent with the hypothesis of ABC transporter-mediated ATP release, showed that MDR possesses a cavity large enough to accommodate and translocate molecules as large as ATP [73].
Localization (release) of ABC in cavity
4) Confidence 0.04 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.14 Pain Relevance 0
Non-structural
       proteins perform functions like actin binding, zinc-binding, calcium-binding, hydrolases, Carbon-Oxygen Lyases, P-type ATPase, proteins belonging to major facilitator family (MFS), secreting main terminal branch (MTB) 
       family, phosphotransfer-driven group translocators and ATP-binding cassette (ABC) family group of proteins. 
Localization (secreting) of ABC
5) Confidence 0.04 Published 2008 Journal Bioinformation Section Abstract Doc Link PMC2586131 Disease Relevance 0.20 Pain Relevance 0
The ATP-binding cassette (ABC) transporter ABCA1 functions to secrete cholesterol from astrocytes and is an important regulator of cholesterol metabolism.
Localization (secrete) of ABC in astrocytes
6) Confidence 0.02 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.28 Pain Relevance 0.04

General Comments

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