INT21660

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Context Info
Confidence 0.61
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 8.51
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 2
liver 1
fibroblasts 1
foot 1
CHM (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 9 100.00 Very High Very High Very High
headache 5 100.00 Very High Very High Very High
cytokine 42 94.04 High High
cva 27 70.80 Quite High
anesthesia 24 50.00 Quite Low
cerebral cortex 6 41.76 Quite Low
imagery 37 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Choroideremia 1162 100.00 Very High Very High Very High
Headache 10 100.00 Very High Very High Very High
Epilepsy 2 100.00 Very High Very High Very High
Syndrome 48 99.98 Very High Very High Very High
Injury 12 99.34 Very High Very High Very High
Adhesions 23 98.70 Very High Very High Very High
Increased Venous Pressure Under Development 20 98.60 Very High Very High Very High
Sleep Disorders 20 96.76 Very High Very High Very High
Migraine With Aura 3 93.04 High High
Heart Rate Under Development 15 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of peripheral cells and primary cultures derived from CHM patients could be extremely helpful since the existing paradigm for CHM pathogenesis is lacking a number of key data regarding the tissue specificity of REP-1 regulation.
Regulation (regulation) of REP-1 associated with choroideremia
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.88 Pain Relevance 0
These results confirm that decreased acidification in lysosomes affects the proteolytic abilities of CHM and control monocytes.


Regulation (affects) of CHM in monocytes associated with choroideremia
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.80 Pain Relevance 0
A number of genes involved in the immune response, small GTPase regulation, secretion, the regulation of transcription, cell adhesion and the regulation of exocytosis were significantly up-and down-regulated in both fibroblasts and monocytes from CHM patients.
Regulation (regulated) of CHM in monocytes associated with choroideremia and adhesions
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.92 Pain Relevance 0
Peripheral cells from CHM patients expose characteristics that were not previously recognized and could used as an alternative models to study the effects of different mutations in the REP-1 gene on mechanism of CHM development in human population.



Regulation (effects) of REP-1 associated with choroideremia
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2793004 Disease Relevance 0.80 Pain Relevance 0.09
REP-1 is involved in post-translational lipid modification (isoprenylation) of monomeric Rab GTPases (Rabs), which are key regulators of vesicular trafficking, phagosome fusion and maturation [1], [6], [7].
Regulation (involved) of REP-1
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.90 Pain Relevance 0
The middle SMS-REP/LCR17pB was also insertion target of the MDLS region in patient 1.
Regulation (target) of REP associated with syndrome
6) Confidence 0.26 Published 2007 Journal Hum Genet Section Body Doc Link PMC1914245 Disease Relevance 0.43 Pain Relevance 0
The use of peripheral cells and primary cultures derived from CHM patients could be extremely helpful since the existing paradigm for CHM pathogenesis is lacking a number of key data regarding the tissue specificity of REP-1 regulation.
Regulation (regulation) of CHM associated with choroideremia
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.92 Pain Relevance 0
In the identification of the 37 foot ulcer patients, TCD was highly sensitive (100%) but less specific (58.3%) than VPT (86.5%; 79.2%) and the monofilaments (91.9%; 76.0%).
Regulation (sensitive) of TCD in foot
8) Confidence 0.23 Published 1997 Journal Diabetes Care Section Body Doc Link 9096991 Disease Relevance 0.07 Pain Relevance 0
The value of TCD in the differential diagnosis of "vascular headache" and in the study of migraine pathophysiology will have to be determined in the future.
Regulation (value) of TCD associated with migraine, headache and increased venous pressure under development
9) Confidence 0.23 Published 1990 Journal Headache Section Abstract Doc Link 2186015 Disease Relevance 0.44 Pain Relevance 0.44
CBF changes during headache-free periods and spontaneous/induced attacks in migraine with and without aura: a TCD and SPECT comparison study.
Regulation (changes) of TCD associated with epilepsy, migraine and headache
10) Confidence 0.15 Published 1999 Journal J Neurosurg Sci Section Title Doc Link 10735768 Disease Relevance 0.30 Pain Relevance 0.37
TCD values were only slightly affected following fentanyl/midazolam.
Regulation (values) of TCD
11) Confidence 0.15 Published 1995 Journal J Clin Monit Section Body Doc Link 7760093 Disease Relevance 0 Pain Relevance 0
A number of genes involved in the immune response, small GTPase regulation, secretion, the regulation of transcription, cell adhesion and the regulation of exocytosis were significantly up-and down-regulated in both fibroblasts and monocytes from CHM patients.
Regulation (regulated) of CHM in fibroblasts associated with choroideremia and adhesions
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.92 Pain Relevance 0
Possible explanations may include the use of vasodilators, the increased sensitivity of the TCD apparatus by removal of the low-pass filter and the avoidance of jugular central venous lines that can theoretically impede regional cerebral venous drainage in small infants and thus decreasing CPP.
Regulation (sensitivity) of TCD
13) Confidence 0.13 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1764902 Disease Relevance 0.15 Pain Relevance 0
From the TCD data, we also calculated the Gosling's pulsatility index (PI) of the MCA in baseline conditions and in correspondence of the maximum CBFV increase during the apnea.
Regulation (calculated) of TCD associated with sleep disorders
14) Confidence 0.12 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.19 Pain Relevance 0
GG was responsible for the TCD data acquisition, participated in the TCD data analysis, and participated in the definition of the experimental protocol.
Regulation (responsible) of TCD
15) Confidence 0.12 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.14 Pain Relevance 0
To define the optimal value of SP and TCD flow velocity that is able to discriminate patients with clamping ischemia, a receiver operator characteristic (ROC) curve was constructed.
Regulation (value) of TCD
16) Confidence 0.09 Published 1997 Journal J. Vasc. Surg. Section Body Doc Link 9423712 Disease Relevance 0 Pain Relevance 0
Cutoff values for both SP and TCD, using the ROC curve, were < or = 50 mm Hg and > or = 70% flow velocity reduction from baseline, respectively.
Regulation (values) of TCD
17) Confidence 0.09 Published 1997 Journal J. Vasc. Surg. Section Body Doc Link 9423712 Disease Relevance 0 Pain Relevance 0
Inter-individual variability of BFI and TCD values was determined by calculating the coefficient of variation (CV) of measurements at each experimental stage.
Regulation (values) of TCD
18) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.13 Pain Relevance 0
Following liver trauma, CPP and CO as well as NIRS and TCD values decreased continuously.
Regulation (values) of TCD in liver associated with injury
19) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1550846 Disease Relevance 0.19 Pain Relevance 0
The magnitude of TCD velocity decline was significantly correlated with the maximal baseline TCD value.
Regulation (value) of TCD
20) Confidence 0.00 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2754089 Disease Relevance 0.33 Pain Relevance 0.04

General Comments

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