INT21662

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Context Info
Confidence 0.51
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.14
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpz) extracellular region (Cpz) proteinaceous extracellular matrix (Cpz)
Anatomy Link Frequency
neuronal 1
Cpz (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 33 100.00 Very High Very High Very High
Dextromethorphan 6 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
qutenza 172 99.50 Very High Very High Very High
opiate 6 86.24 High High
depression 14 85.92 High High
spinal dorsal horn 30 85.84 High High
tolerance 1 80.76 Quite High
Action potential 28 80.16 Quite High
Physical dependence 1 80.08 Quite High
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 1 94.80 High High
Tremor 1 90.56 High High
Appetite Loss 1 88.08 High High
Depression 14 85.92 High High
Pain 11 85.92 High High
Akathisia 1 85.36 High High
Sleep Disorders 1 84.24 Quite High
Vomiting 2 83.44 Quite High
Diarrhoea 1 82.80 Quite High
Drug Dependence 1 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However the current synthetic methods used for the total synthesis of CPZ are lengthy, involve multiple purification steps, and produce low yields.
Gene_expression (synthesis) of CPZ
1) Confidence 0.51 Published 2004 Journal Comb. Chem. High Throughput Screen. Section Abstract Doc Link 15032662 Disease Relevance 0 Pain Relevance 0.05
Here we describe a new and highly efficient synthesis of benzazepine 3, a synthetic precursor of CPZ, in only two steps and 59% overall yield from a commercially available tetralone 2 via a Schmidt reaction as a key step.
Gene_expression (synthesis) of CPZ
2) Confidence 0.45 Published 2004 Journal Comb. Chem. High Throughput Screen. Section Abstract Doc Link 15032662 Disease Relevance 0 Pain Relevance 0.05
The remaining subjects received 15 mg non-opioid antitussive dextromethorphan (DM) instead of CPZ.
Gene_expression (received) of CPZ associated with dextromethorphan and opioid
3) Confidence 0.20 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2187002 Disease Relevance 1.05 Pain Relevance 0.70
In this study, we showed that inhibition of the neuronal excitation by CAP was not observed in the presence of CPZ.
Gene_expression (presence) of CPZ in neuronal associated with qutenza
4) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434724 Disease Relevance 0 Pain Relevance 1.34
The inhibition by CAP was not observed in the presence of the TRPV1 channels antagonist, capsazepine [18] (CPZ, 20 ?
Gene_expression (antagonist) of CPZ associated with qutenza and antagonist
5) Confidence 0.14 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434724 Disease Relevance 0.09 Pain Relevance 1.22

General Comments

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