INT216670

Context Info Confidence 0.35 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.54 Pain Relevance 1.90

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn) extracellular matrix organization (Postn)

Anatomy Link Frequency upper 1 neutrophil 1 Postn (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 111 100.00 Pain 61 99.98 Morphine 61 98.68 Mcgill questionnaire 4 83.40 Analgesic 11 79.16 peripheral neuropathy 6 76.72 Opioid 19 55.68 Inflammation 10 54.24 Inflammatory mediators 1 51.20 Neuropathic pain 11 50.00

Disease Link Frequency Relevance Heat Pain 73 99.98 Injury 45 93.32 Urological Neuroanatomy 14 90.04 Peripheral Neuropathy 12 76.72 Wound Healing 2 71.16 Infection 7 69.96 Nociception 26 62.36 INFLAMMATION 12 54.24 Stress 32 50.00 Neuropathic Pain 23 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elastic bands of 0.5 mm thickness were inserted between the first and second upper molars of the wild-type mice and littermates homozygous for periostin gene depletion and left there for 3 days.

Negative_regulation (depletion) of periostin in upper

1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

Pain reduction effects of Neuragen PN® and the placebo were measured using the VAS 30 minutes before (Pre) and after (Post) treatment application.

Negative_regulation (reduction) of Neuragen PN associated with pain

2) Confidence 0.09 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2883533 Disease Relevance 0.67 Pain Relevance 0.68

However, with the exception of KC levels, peri-incisional cytokine levels were reduced by the 100-fold lower 0.1 mg/kg morphine dose, a dose at which neutrophil infiltration was unaffected.

Negative_regulation (reduced) of peri-incisional in neutrophil associated with morphine and cytokine

3) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2096620 Disease Relevance 0.87 Pain Relevance 1.22

General Comments

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