INT216709

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.48
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SELP, PSMG1) extracellular space (SELP) endoplasmic reticulum (PSMG1)
cell adhesion (SELP) nucleolus (SELP) plasma membrane (SELP)
Anatomy Link Frequency
platelet 5
SELP (Homo sapiens)
PSMG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 8 97.24 Very High Very High Very High
antagonist 26 90.72 High High
aspirin 36 82.40 Quite High
agonist 12 5.00 Very Low Very Low Very Low
adenocard 6 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 66 100.00 Very High Very High Very High
Cv General 3 Under Development 8 97.24 Very High Very High Very High
Thrombosis 12 84.92 Quite High
Acute Coronary Syndrome 2 81.64 Quite High
Coronary Artery Disease 14 5.00 Very Low Very Low Very Low
Myocardial Infarction 9 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low
Coagulation Disorder 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
P-selectin Binding (complex) of PAC-1 in Platelet associated with heart rate under development
1) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.05
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
CD62P Binding (complex) of PAC-1 in Platelet associated with heart rate under development
2) Confidence 0.08 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.05
The remaining 23 patients (44.2%) were defined as intermediate responders, due to a high (above the 1st quartile of normal) percentage of platelets expressing CD62P and a low (below the 1st quartile of normal) percentage of platelets binding PAC-1 (2 patients, 3.8%) or vice versa (21 patients, 40.3%).
CD62P Binding (binding) of PAC-1 in platelets associated with heart rate under development
3) Confidence 0.07 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.41 Pain Relevance 0
We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1) Flow cytometry (FC) to measure platelet membrane expression of P-selectin (CD62P) and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG) E1; 2) VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU) or % of inhibition (% inhibition).


CD62P Binding (binding) of PAC-1 in platelet associated with heart rate under development and angina
4) Confidence 0.06 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0.14
We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1) Flow cytometry (FC) to measure platelet membrane expression of P-selectin (CD62P) and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG) E1; 2) VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU) or % of inhibition (% inhibition).


P-selectin Binding (binding) of PAC-1 in platelet associated with heart rate under development and angina
5) Confidence 0.06 Published 2009 Journal Thromb J Section Abstract Doc Link PMC2683811 Disease Relevance 0.35 Pain Relevance 0.14

General Comments

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