INT216729

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.76
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (PSMG1) cytoplasm (PSMG1)
Anatomy Link Frequency
platelet 2
PSMG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 13 90.72 High High
agonist 9 87.36 High High
Angina 7 24.44 Low Low
aspirin 24 14.16 Low Low
adenocard 6 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 63 100.00 Very High Very High Very High
Acute Coronary Syndrome 1 80.72 Quite High
Coronary Artery Disease 13 39.64 Quite Low
Cv General 3 Under Development 7 24.44 Low Low
Coagulation Disorder 3 23.92 Low Low
Myocardial Infarction 6 23.24 Low Low
Thrombosis 12 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two mAbs were used: fluorescein isothiocyanate (FITC)-conjugated PAC-1 (Beckton Dickinson, San Jose, CA), which binds to the activated conformation of GP IIb-IIIa, and an anti-P selectin mAb (also known as CD62P)labelled with R-phycoerythrin (PE) (Caltag Laboratories, Burlingame, CA).
Positive_regulation (conjugated) of PAC-1 associated with heart rate under development
1) Confidence 0.11 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.10 Pain Relevance 0
As expected, the median values of CD62P expression and PAC-1 binding in patients were significantly lower than in controls only in high responders (p < 0.0001) and intermediate responders (p < 0.0001 and p < 0.02, respectively).


Positive_regulation (values) of PAC-1 associated with heart rate under development
2) Confidence 0.11 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.38 Pain Relevance 0
For these reasons, which may confound the interpretation of the functional state of P2Y12, we elected to measure surface translocation of P-selectin as an activation marker possibly more directly linked to ADP-induced platelet stimulation, as well as PAC-1 binding that, by reflecting GP IIb-IIIa activation, provides information consistent with that of aggregation assays.
Positive_regulation (induced) of PAC-1 in platelet associated with heart rate under development
3) Confidence 0.10 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.10 Pain Relevance 0.04
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
Positive_regulation (activated) of PAC-1 in Platelet associated with heart rate under development
4) Confidence 0.10 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox