INT216735

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.68
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Matn1) proteinaceous extracellular matrix (Matn1)
Matn1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 144 100.00 Very High Very High Very High
antagonist 47 89.60 High High
agonist 32 88.96 High High
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 110 99.32 Very High Very High Very High
Hematological Disease 30 98.04 Very High Very High Very High
Disease 40 91.44 High High
Myeloid Leukemia 280 88.48 High High
Targeted Disruption 10 84.96 Quite High
Leukemia 85 84.80 Quite High
Breast Cancer 10 80.76 Quite High
Chronic Myeloid Leukemia 5 74.60 Quite High
Hematologic Neoplasms 10 49.92 Quite Low
Myelodysplastic Syndromes 5 43.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With a Ki value of 5 µM at human adenosine A2A receptors [3H]PSB-298 is highly selective for adenosine A2B over A2A receptors [16].
Gene_expression (selective) of M at associated with adenocard
1) Confidence 0.65 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.72
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Gene_expression (overexpressing) of CMP
2) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0
Overexpression of miR-29a enhances proliferation of MPP and 293T cells but does not significantly alter MPP self-renewal, yet overexpression of miR-29a in CMP or GMP is sufficient to induce self-renewal but not proliferation, suggesting that miR-29a exerts stage-specific and cell context–specific effects.
Gene_expression (overexpression) of CMP
3) Confidence 0.09 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.39 Pain Relevance 0
We sorted MPP, CMP, and GMP from control (WT or empty retrovirus–transduced chimeric mice) or miR-29a–overexpressing primary chimeric mice before MPD development (?
Gene_expression (overexpressing) of CMP associated with myeloproliferative disorder
4) Confidence 0.08 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.28 Pain Relevance 0
Mice transplanted with miR-29a–expressing CMP or GMP possessed donor-derived CMP and GMP, respectively, as well as their differentiated GFP+ progeny (Mac1+Gr-1+ cells), even 2 mo after the transplantation (Fig. 3 e).
Gene_expression (expressing) of CMP
5) Confidence 0.08 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.11 Pain Relevance 0
To assess the stage of hematopoiesis at which miR-29a exerts its promyeloid differentiation and proliferative effects, we sorted MPP, CMP, and GMP from miR-29a–expressing chimeric mice and assessed the ability of single sorted progenitors to proliferate and differentiate in vitro using liquid cultures. miR-29a MPP (Lin?
Gene_expression (expressing) of CMP associated with hematological disease
6) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.23 Pain Relevance 0

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