INT216749

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.89
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2B) signal transducer activity (ADORA2B)
ADORA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 278 100.00 Very High Very High Very High
antagonist 154 99.96 Very High Very High Very High
agonist 198 99.24 Very High Very High Very High
Analgesic 5 98.36 Very High Very High Very High
Opioid 4 92.40 High High
analgesia 3 92.12 High High
chemokine 3 91.12 High High
cytokine 3 90.56 High High
Hippocampus 3 79.76 Quite High
Calcium channel 3 77.60 Quite High
Disease Link Frequency Relevance Heat
Asthma 16 99.08 Very High Very High Very High
Airway Remodeling 3 98.52 Very High Very High Very High
Nociception 6 96.04 Very High Very High Very High
Acute Erythroblastic Leukemia 3 73.92 Quite High
INFLAMMATION 17 70.80 Quite High
Neurodegenerative Disease 3 59.76 Quite High
Diabetic Retinopathy 7 58.88 Quite High
Disease 7 55.92 Quite High
Cancer 7 54.72 Quite High
Diabetes Mellitus 5 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A2B are coupled to different signalling pathways such as stimulation of adenylate cyclase through Gs proteins and accumulation of intracellular calcium.
Positive_regulation (coupled) of A2B
1) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.07 Pain Relevance 0.21
Interestingly a role of A2B receptors has also been observed in the analgesic effects of caffeine in an acute animal model of nociception, suggesting that specific A2B antagonists might be valuable adjuvant drugs for opioid analgesia with minimal side effects [30].
Positive_regulation (role) of A2B associated with nociception, antagonist, analgesic, opioid and analgesia
2) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.48 Pain Relevance 0.48
Adenosine, an ubiquitous nucleoside released from metabolically active or stressed cells, is known to act as an important regulatory molecule through activation of cell surface receptors named A1, A2A, A2B and A3, all of which belong to the G protein-coupled superfamily of receptors [1].
Positive_regulation (activation) of A2B associated with adenocard
3) Confidence 0.35 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.29 Pain Relevance 0.13
We tried to displace the A1 selective radioligand [3H]CHA with increasing concentrations of the adenosine A2B receptor antagonists.
Positive_regulation (increasing) of adenosine A2B receptor associated with adenocard and antagonist
4) Confidence 0.31 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.05 Pain Relevance 0.38
Activation of A2A and A2B receptors leads to a Gs-mediated stimulation of this enzyme [1].
Positive_regulation (Activation) of A2B
5) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.21
Adenosine receptors (ARs) are G protein-coupled receptors, consisting of A1, A2A, A2B and A3 subtypes, activated by the endogenous agonist adenosine and blocked by natural antagonists, such as caffeine and theophylline.
Positive_regulation (activated) of A2B associated with adenocard, antagonist and agonist
6) Confidence 0.01 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.29

General Comments

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