INT21678

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Context Info
Confidence 0.55
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 10.11
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
blood 6
CNS 2
proximal 1
bladder 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 98.44 Very High Very High Very High
anesthesia 3 95.88 Very High Very High Very High
Pain 24 94.04 High High
Demyelination 6 89.68 High High
Inflammation 17 86.80 High High
carpal tunnel syndrome 3 84.64 Quite High
spinal inflammation 1 83.96 Quite High
imagery 3 78.20 Quite High
cytokine 13 55.44 Quite High
agonist 1 33.28 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 8 99.78 Very High Very High Very High
Bladder Cancer 10 99.32 Very High Very High Very High
Amyloid Plaque 1 98.84 Very High Very High Very High
Disease 5 98.60 Very High Very High Very High
Cancer 14 98.48 Very High Very High Very High
Amyloidosis 46 98.20 Very High Very High Very High
Arthralgia 20 94.04 High High
Alzheimer's Dementia 6 93.24 High High
Uremia 4 89.84 High High
Demyelinating Disease 8 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of circulating beta2-microglobulin level for the treatment of dialysis-related amyloidosis.
Negative_regulation (Reduction) of beta2-microglobulin associated with amyloidosis
1) Confidence 0.55 Published 2001 Journal Nephrol. Dial. Transplant. Section Title Doc Link 11402095 Disease Relevance 0.74 Pain Relevance 0.13
However, treatment of HDF with HPM for more than 6 months caused no remarkable improvement in clinical symptoms of patients, and serum beta 2M levels decreased in only two out of 15 patients.
Negative_regulation (decreased) of beta 2M
2) Confidence 0.50 Published 1988 Journal Artif Organs Section Abstract Doc Link 3281635 Disease Relevance 0.30 Pain Relevance 0.08
New adsorption column (Lixelle) to eliminate beta2-microglobulin for direct hemoperfusion.
Negative_regulation (eliminate) of beta2-microglobulin
3) Confidence 0.43 Published 1998 Journal Ther Apher Section Title Doc Link 10227783 Disease Relevance 0.25 Pain Relevance 0.08
The Lixelle column is an adsorbent column used to eliminate beta2-microglobulin (beta2M) selectively from circulating blood of dialysis related amyloidosis (DRA) patients, which is used in combination with a dialyzer in series.
Negative_regulation (eliminate) of beta2M in blood associated with amyloidosis
4) Confidence 0.43 Published 1998 Journal Ther Apher Section Abstract Doc Link 10227783 Disease Relevance 0.23 Pain Relevance 0.07
The Lixelle column is an adsorbent column used to eliminate beta2-microglobulin (beta2M) selectively from circulating blood of dialysis related amyloidosis (DRA) patients, which is used in combination with a dialyzer in series.
Negative_regulation (eliminate) of beta2-microglobulin in blood associated with amyloidosis
5) Confidence 0.43 Published 1998 Journal Ther Apher Section Abstract Doc Link 10227783 Disease Relevance 0.23 Pain Relevance 0.07
Recently, a direct haemoperfusion method using selective beta2m absorption column to eliminate circulating beta2m has been introduced into clinical practice.
Negative_regulation (eliminate) of beta2m
6) Confidence 0.41 Published 2001 Journal Nephrol. Dial. Transplant. Section Abstract Doc Link 11402095 Disease Relevance 0.72 Pain Relevance 0.14
The column has such a high capacity for adsorbing beta2M that the most intensive removal of beta2M has been possible.
Negative_regulation (removal) of beta2M
7) Confidence 0.38 Published 1998 Journal Ther Apher Section Abstract Doc Link 10227783 Disease Relevance 0.26 Pain Relevance 0.09
To distinguish between the local effects of transgene-encoded TNF and the potential encephalitogenic effects of immune infiltrates upon CNS disease pathogenesis, we have backcrossed Tg6074 TNF-transgenic mice to mice deficient in CD4, beta2-microglobulin (beta2m), immunoglobulin mu chain (Igmu) or recombination activation gene-1 (Rag-1).
Negative_regulation (deficient) of beta2-microglobulin in CNS associated with targeted disruption, central nervous system and disease
8) Confidence 0.38 Published 1999 Journal Eur. J. Immunol. Section Abstract Doc Link 10092095 Disease Relevance 0.94 Pain Relevance 0.47
To distinguish between the local effects of transgene-encoded TNF and the potential encephalitogenic effects of immune infiltrates upon CNS disease pathogenesis, we have backcrossed Tg6074 TNF-transgenic mice to mice deficient in CD4, beta2-microglobulin (beta2m), immunoglobulin mu chain (Igmu) or recombination activation gene-1 (Rag-1).
Negative_regulation (deficient) of beta2m in CNS associated with targeted disruption, central nervous system and disease
9) Confidence 0.38 Published 1999 Journal Eur. J. Immunol. Section Abstract Doc Link 10092095 Disease Relevance 0.94 Pain Relevance 0.47
Among 27 patients treated with these methods, significant beta 2M removal was noted in HDF with HPM and HD with polyacrylonitril (PAN) membrane.
Negative_regulation (removal) of beta 2M
10) Confidence 0.37 Published 1988 Journal Artif Organs Section Abstract Doc Link 3281635 Disease Relevance 0.33 Pain Relevance 0.08
The tubular reabsorption of (123)I-beta(2)-microglobulin was strongly impaired in the Clcn5 knockout mice, with defective tubular processing and loss of the native tracer in urine, reflecting proximal tubule dysfunction.
Negative_regulation (impaired) of microglobulin in proximal associated with targeted disruption
11) Confidence 0.36 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19955188 Disease Relevance 0.27 Pain Relevance 0.21
In the knockout phenotype lacking beta2m, ANKENT occurrence is significantly reduced (P = 0.016).
Negative_regulation (lacking) of beta2m associated with targeted disruption
12) Confidence 0.34 Published 1997 Journal Immunogenetics Section Abstract Doc Link 9148786 Disease Relevance 0.90 Pain Relevance 0.08
However, proof is lacking that amyloid deposits are decreased by long-term use of dialysis techniques to eliminate beta2-m.
Negative_regulation (eliminate) of beta2-m associated with amyloid plaque
13) Confidence 0.31 Published 2003 Journal Nephrology (Carlton) Section Abstract Doc Link 15012691 Disease Relevance 0.87 Pain Relevance 0.06
Lixelle is a direct hemoperfusion-type adsorbent column developed for selective elimination of beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA).
Negative_regulation (elimination) of beta2-microglobulin in blood associated with amyloidosis
14) Confidence 0.25 Published 2003 Journal Ther Apher Dial Section Abstract Doc Link 12921124 Disease Relevance 0.44 Pain Relevance 0.08
Lixelle is a direct hemoperfusion-type adsorbent column developed for selective elimination of beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA).
Negative_regulation (elimination) of beta2-m in blood associated with amyloidosis
15) Confidence 0.25 Published 2003 Journal Ther Apher Dial Section Abstract Doc Link 12921124 Disease Relevance 0.44 Pain Relevance 0.08
A down-regulation of HLA-ABC and beta 2-microglobulin have been reported in microdissected tumor tissue derived from bladder carcinomas [61].
Negative_regulation (regulation) of microglobulin in bladder associated with cancer and bladder cancer
16) Confidence 0.19 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2212656 Disease Relevance 0.62 Pain Relevance 0
Lixelle is a direct hemoperfusion-type adsorption column that was developed to selectively eliminate beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA).
Negative_regulation (eliminate) of beta2-m in blood associated with amyloidosis
17) Confidence 0.14 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16168723 Disease Relevance 0.40 Pain Relevance 0.13
Lixelle is a direct hemoperfusion-type adsorption column that was developed to selectively eliminate beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA).
Negative_regulation (eliminate) of beta2-microglobulin in blood associated with amyloidosis
18) Confidence 0.14 Published 2005 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16168723 Disease Relevance 0.39 Pain Relevance 0.13
Push/pull HDF showed significantly greater removal of beta 2-microglobulin (beta 2-m) and other small molecular proteins than HD, and serum beta 2-m was significantly lower in concentration with push/pull HDF than HD.
Negative_regulation (removal) of beta 2-m
19) Confidence 0.11 Published 1990 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 2190031 Disease Relevance 0.42 Pain Relevance 0.33
Push/pull HDF showed significantly greater removal of beta 2-microglobulin (beta 2-m) and other small molecular proteins than HD, and serum beta 2-m was significantly lower in concentration with push/pull HDF than HD.
Negative_regulation (lower) of beta 2-m
20) Confidence 0.10 Published 1990 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 2190031 Disease Relevance 0.43 Pain Relevance 0.34

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