INT21679

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Context Info
Confidence 0.26
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 4.59
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
PGE1 2
eosinophil 2
monocytes 1
leucocytes 1
nasal 1
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 6 99.66 Very High Very High Very High
Morphine 18 99.52 Very High Very High Very High
Inflammation 85 96.52 Very High Very High Very High
agonist 5 94.64 High High
Opioid 6 93.64 High High
Potency 2 89.04 High High
Catecholamine 6 82.56 Quite High
Dopamine 4 81.32 Quite High
narcan 3 78.00 Quite High
withdrawal 3 75.36 Quite High
Disease Link Frequency Relevance Heat
Nasal Polyps 72 99.68 Very High Very High Very High
Chronic Sinusitis 72 98.74 Very High Very High Very High
INFLAMMATION 104 96.52 Very High Very High Very High
Rhinitis 48 96.00 Very High Very High Very High
Disease 45 95.24 Very High Very High Very High
Polyps 9 92.16 High High
Vibrio Infection 3 81.32 Quite High
Targeted Disruption 2 77.56 Quite High
Neuroblastoma 6 75.00 Quite High
Morphine Dependence 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also observed that EP2 and EP4 receptors are up-regulated in chronic rhinosinusitis and nasal polyp tissue compared to control subjects; however, EP1 and EP3 transcripts were statistically decreased in the nasal polyp patients.
Negative_regulation (decreased) of EP1 in nasal associated with chronic sinusitis and nasal polyps
1) Confidence 0.26 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.52 Pain Relevance 0.25
Eicosanoid receptors mRNA pattern observed suggests that down-regulation of EP1 and EP3 in CRS-NP and up-regulation EP2 and EP4 in CRS and CRS-NP groups may have some role in the development of the diseases and their regulation may not be directly linked to eosinophil activation but involve post-transcriptional events mainly related to other inflammatory cell sources.



Negative_regulation (down-regulation) of EP1 in eosinophil associated with inflammation and disease
2) Confidence 0.19 Published 2006 Journal Respir Res Section Abstract Doc Link PMC1481584 Disease Relevance 0.70 Pain Relevance 0.13
Eicosanoid receptors mRNA pattern observed in our patient's groups suggest that down-regulation of EP1 and EP3 in the nasal polyp tissue and up-regulation EP2 and EP4 in both chronic rhinosinusitis groups may play a role in the development of the diseases and their regulation do not directly depend of eosinophil activation.
Negative_regulation (regulation) of EP1 in eosinophil associated with chronic sinusitis, nasal polyps and disease
3) Confidence 0.19 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.33 Pain Relevance 0.11
On receptor level, chronic morphine treatment was found to reduce PGE1 receptor number (Bmax) by approximately 40%, whereas their affinity slightly increased.
Negative_regulation (reduce) of PGE1 receptor associated with morphine
4) Confidence 0.17 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.22 Pain Relevance 0.46
Binding experiments performed in the presence of GTPgammaS (100 mu M) further indicate that the decrease in PGE1 receptor density is associated with a loss of functionally G protein-coupled receptors.
Negative_regulation (decrease) of PGE1 receptor
5) Confidence 0.17 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.23 Pain Relevance 0.45
Evaluation of the functional interaction between PGE1 receptors and GS in situ by application of a C-terminal anti-GSalpha antibody revealed a more intense coupling efficiency between these two entities, since a significant higher amount of antibody (2.3-fold) was required in morphine dependent cell membranes to half-maximally attenuate PGE1 receptor-stimulated adenylate cyclase activity.
Negative_regulation (attenuate) of PGE1 receptor associated with morphine
6) Confidence 0.11 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.30 Pain Relevance 0.55
Clonidine (3 nM-1 microM) diminished the PGE1 (1 microM)-stimulated AC by a maximum of 30%.
Negative_regulation (diminished) of PGE1 in PGE1 associated with clonidine
7) Confidence 0.08 Published 1987 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 3426758 Disease Relevance 0 Pain Relevance 0.23
In leucocytes, acemetacin and indomethacin were more potent cyclo-oxygenase inhibitors than in the gastric mucosa, and both reduced the PGE levels to similar extents (70-98% and 72-100% respectively, n = 5).
Negative_regulation (reduced) of PGE in leucocytes
8) Confidence 0.06 Published 1993 Journal Int J Tissue React Section Abstract Doc Link 8144313 Disease Relevance 0 Pain Relevance 0
In serum, a >90% inhibition of TxB(2) and PGE(2) occurred within 30 min of naproxen administration.
Negative_regulation (inhibition) of PGE
9) Confidence 0.04 Published 2006 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 16393293 Disease Relevance 0 Pain Relevance 0
AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM.
Negative_regulation (inhibition) of PGE
10) Confidence 0.03 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19925781 Disease Relevance 0.15 Pain Relevance 0.07
In LPS-stimulated monocytes, AF3442 caused a concentration-dependent reduction of PGE(2) biosynthesis with an IC(50) of 0.41microM.
Negative_regulation (reduction) of PGE in monocytes
11) Confidence 0.03 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 19925781 Disease Relevance 0.14 Pain Relevance 0.07
At high concentrations, R(-)-isoproterenol was more potent than either the S(+)-isomer or desoxy analog, N-isopropyldopamine, in the reversal of PGE1 inhibition of ADP aggregation.
Negative_regulation (inhibition) of PGE1 in PGE1
12) Confidence 0.03 Published 1990 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2190233 Disease Relevance 0 Pain Relevance 0.53

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