INT216807

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Svs4) extracellular region (Svs4)
Anatomy Link Frequency
dendrites 1
spike 1
Svs4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 6 99.88 Very High Very High Very High
antagonist 8 98.78 Very High Very High Very High
Action potential 30 98.14 Very High Very High Very High
sodium channel 8 92.16 High High
adenocard 20 81.40 Quite High
agonist 18 50.00 Quite Low
Pyramidal cell 2 46.08 Quite Low
addiction 10 36.60 Quite Low
medulla 2 13.44 Low Low
depression 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 6 46.72 Quite Low
Depression 20 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Blister 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results suggest a mechanism for burst generation in olivary neurons: the initial sodium action potential is initiated in the axon and backpropagates into the dendrites, activating the calcium channels that underlie the ADP.
ADP Binding (underlie) of in dendrites associated with action potential and calcium channel
1) Confidence 0.25 Published 2009 Journal Neuron Section Body Doc Link PMC2777250 Disease Relevance 0 Pain Relevance 0.29
In contrast, a rebound action potential triggered following the termination of hyperpolarizing current pulses lacked the pronounced ADP and was only associated with a single axonal spike (Figure 1D).
ADP Binding (associated) of in spike associated with action potential
2) Confidence 0.25 Published 2009 Journal Neuron Section Body Doc Link PMC2777250 Disease Relevance 0 Pain Relevance 0.17
As depicted by the exemplifying Ca2+ traces, ADP triggered a single Ca2+ peak (c) while UTP caused a long-lasting oscillatory Ca2+ activity (d)Figure 7Ca2+ signal induced by low doses of uridine 5?
ADP Binding (triggered) of
3) Confidence 0.03 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.04
(b), (d) As expected, the P2Y1 antagonist MRS2179 does not affect the response to UTP but it does not inhibit even that to ADP, outlining the presence of ADP-sensitive receptors other than P2Y1 (n = 59–164)
ADP Neg (inhibit) Binding (inhibit) of associated with antagonist
4) Confidence 0.03 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.21

General Comments

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