INT21681

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Context Info
Confidence 0.66
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 33.95
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34)
extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)
Anatomy Link Frequency
smooth muscle 3
Bone marrow 2
blood 2
mononuclear cells 2
endothelial cells 2
CD34 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 41 98.76 Very High Very High Very High
rheumatoid arthritis 64 97.84 Very High Very High Very High
Arthritis 113 97.64 Very High Very High Very High
Pain 26 97.44 Very High Very High Very High
Inflammation 138 95.72 Very High Very High Very High
Dopamine 5 95.24 Very High Very High Very High
neuralgia 3 94.68 High High
cytokine 83 92.60 High High
Catecholamine 2 92.52 High High
fibrosis 9 87.60 High High
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 20 99.80 Very High Very High Very High
Cancer 297 99.78 Very High Very High Very High
Coronary Artery Disease 240 99.78 Very High Very High Very High
Myocardial Infarction 166 99.68 Very High Very High Very High
Muscular Dystrophy 213 99.20 Very High Very High Very High
Dermatofibroma 10 98.82 Very High Very High Very High
Cv General 3 Under Development 44 98.76 Very High Very High Very High
Hypersensitivity 42 98.24 Very High Very High Very High
Hematological Disease 6 98.24 Very High Very High Very High
Solitary Fibrous Tumors 15 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confirming our previous results, the 4-week de-novo treatment of atorvastatin in stable CAD evoked an increase only of CD45dimCD34+KDR+ EPC, confirming our previous study [24].
Positive_regulation (increase) of CD45dimCD34 associated with coronary artery disease
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.58 Pain Relevance 0
Of the many studies in this patient group, Shintani et al were the first to describe a rapid and significant increase in the CD34+ EPC numbers, which reached a maximum at 7 days after the onset of ischaemia in acute myocardial infarction (AMI) [48].
Positive_regulation (increase) of CD34 associated with cv unclassified under development and myocardial infarction
2) Confidence 0.65 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0.83 Pain Relevance 0.09
The mobilization of myeloblasts, promyelocytes, myelocytes, and metamyelocytes coincided with the pronounced increase of CD34 + PBPC observed on day 4.
Positive_regulation (increase) of CD34 in myeloblasts
3) Confidence 0.62 Published 1999 Journal Ann. Hematol. Section Abstract Doc Link 10211753 Disease Relevance 0.16 Pain Relevance 0.14
While we correlated an increase in hematopoietic colonies with Stem-Kine induced upregulation of peripheral blood CD34 and CD133 cells, given that these markers are also found on EPC [25], we evaluated the possibility that circulating EPC numbers were also increased.
Positive_regulation (upregulation) of CD34 in Stem
4) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.44 Pain Relevance 0
Augmentation of both CD133 and CD34 cells in circulation was observed, as well as KDR-1+/CD34+ EPC capable of forming endothelial colonies.
Positive_regulation (Augmentation) of CD34
5) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.19 Pain Relevance 0
We show that CD34+ cell circulation is fivefold enhanced by rHuGM-CSF 5.5 protein micrograms/kg/day by continuous intravenous infusion for 14 days after HD-CTX.
Positive_regulation (enhanced) of CD34
6) Confidence 0.50 Published 1989 Journal Blood Section Abstract Doc Link 2478216 Disease Relevance 0.18 Pain Relevance 0.05
In HD-CTX treated patients, CD34+ cell circulation is 5-fold enhanced by rhGM-CSF 5.5 micrograms/kg/day by continuous iv infusion for 14 days.
Positive_regulation (enhanced) of CD34
7) Confidence 0.50 Published 1990 Journal Haematologica Section Abstract Doc Link 2190884 Disease Relevance 0.14 Pain Relevance 0.06
The gene expressions in adhesive subacromial bursae were approximately threefold to fourfold greater than those in nonadhesive bursae for the genes for Type I and Type III procollagens, CD34 antigen in vascular endothelium, hyaluronan synthase-3, and interferon-gamma.
Positive_regulation (bursae) of CD34 in vascular endothelium
8) Confidence 0.49 Published 2003 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 12838053 Disease Relevance 0.31 Pain Relevance 0.15
After surgery, diagnosis of SFT was based on characteristic histopathological findings, especially on immunohistochemical positive staining for CD34 antigen.
Positive_regulation (staining) of CD34 associated with solitary fibrous tumors
9) Confidence 0.49 Published 2004 Journal J Neurosurg Sci Section Abstract Doc Link 15257266 Disease Relevance 0.67 Pain Relevance 0.17
Apheresis was performed, obtaining 50 mL of blood with a high rate of EPCs (CD34(+) and CD133(+) cells were counted).
Positive_regulation (rate) of CD34 in blood
10) Confidence 0.49 Published 2010 Journal Ann Vasc Surg Section Body Doc Link 20142004 Disease Relevance 0 Pain Relevance 0
The cytoplasm of some of the atypical endothelial cells was immunohistochemically positive for vimentin, factor VIII-related antigen, CD 34, and thrombomodulin.
Positive_regulation (positive) of CD 34 in endothelial cells
11) Confidence 0.49 Published 1998 Journal Brain Tumor Pathol Section Abstract Doc Link 10328547 Disease Relevance 0.39 Pain Relevance 0.08
The tumor cells were all immunoreactive for vimentin, CD 34, and focally actin-positive in one case, but not for keratin, desmin, S-100 protein, carcinoembryonic antigen, alpha 1-ACT and F VIII-related antigen, supported a primitive mesenchymal origin. p53 protein was expressed in two of the malignant cases.
Positive_regulation (immunoreactive) of CD 34 associated with malignant neoplastic disease and cancer
12) Confidence 0.49 Published 1999 Journal Lung Cancer Section Abstract Doc Link 10100146 Disease Relevance 2.29 Pain Relevance 0.12
A strongly positive stain result for both factor VIII-related antigen and the fixation-resistant CD34 molecule identified these cells as endothelial.
Positive_regulation (fixation-resistant) of CD34 molecule
13) Confidence 0.49 Published 1994 Journal J. Vasc. Surg. Section Abstract Doc Link 8126870 Disease Relevance 0.32 Pain Relevance 0.05
Increases of CD34+ cell counts were correlated with increases of colony-forming unit-granulocyte macrophage (peak, day 7).
Positive_regulation (Increases) of CD34 in granulocyte
14) Confidence 0.48 Published 1995 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 7828379 Disease Relevance 0.24 Pain Relevance 0.08
The immunohistochemical staining revealed an intense CD34 and bcl-2 immunoreactivity.
Positive_regulation (intense) of CD34
15) Confidence 0.48 Published 2004 Journal Yonsei Med. J. Section Abstract Doc Link 15227752 Disease Relevance 0.80 Pain Relevance 0.07
0.37, p<0.07) towards increased number of CD45dimCD34+KDR+-cells with time of first angina, but not with duration of pain or time to last angina.
Positive_regulation (increased) of CD45dimCD34 associated with pain and cva
16) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 1.21 Pain Relevance 0.20
In 25 control subjects, 65 patients with coronary artery disease (CAD; 40 stable CAD, 25 acute coronary syndrome/acute myocardial infarction (ACS)), EPC were quantified using the following approach: Whole blood was incubated with CD45, KDR, and CD34.
Positive_regulation (incubated) of CD34 in blood associated with acute coronary syndrome, coronary artery disease and myocardial infarction
17) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2972200 Disease Relevance 0.87 Pain Relevance 0
CD34+, or CD45brightCD34+ cells were quantified for KDR expression.
Positive_regulation (quantified) of CD34
18) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.15 Pain Relevance 0
The level of CD34+ cells was increased by 20-fold, and did not differ between days 5 and 6.
Positive_regulation (increased) of CD34
19) Confidence 0.46 Published 1999 Journal Exp. Hematol. Section Abstract Doc Link 9923453 Disease Relevance 0.57 Pain Relevance 0
The specific roles of these cells are uncertain; however it is possible that these cells may differentiate into endothelial cells, since a previous study showed that a subset of CD34-positive cells express AC133 as a true functional marker of endothelial progenitor cells.21
Positive_regulation (subset) of CD34 in endothelial cells
20) Confidence 0.45 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.14 Pain Relevance 0.03

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