INT21682

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 13.19
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34)
extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)
Anatomy Link Frequency
smooth muscle 5
blood 1
tube 1
muscle 1
vessels 1
CD34 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 5 96.88 Very High Very High Very High
anesthesia 4 96.64 Very High Very High Very High
Inflammation 7 92.48 High High
Pain 9 90.56 High High
abdominal pain 6 82.88 Quite High
imagery 1 77.68 Quite High
Chronic pancreatitis 2 76.16 Quite High
Angina 9 71.20 Quite High
Spinal cord 2 66.00 Quite High
pain flank 1 61.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 86 98.34 Very High Very High Very High
Hemangioma 4 98.32 Very High Very High Very High
Coronary Artery Disease 101 98.26 Very High Very High Very High
Gastrointestinal Stromal Tumor 36 98.16 Very High Very High Very High
Neurilemmoma 9 98.14 Very High Very High Very High
Necrosis 6 97.88 Very High Very High Very High
Thrombosis 21 97.70 Very High Very High Very High
Malignant Fibrous Histiocytoma 6 96.96 Very High Very High Very High
Fibrosis 5 96.88 Very High Very High Very High
Vasculitis 3 95.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical examination revealed reactivity to c-KIT and CD34, consistent with the diagnostic criteria for GIST, with low mitotic activity (< 5/50 HPF).
CD34 Binding (reactivity) of associated with gastrointestinal stromal tumor
1) Confidence 0.47 Published 2009 Journal Tumori Section Abstract Doc Link 19579871 Disease Relevance 1.38 Pain Relevance 0.08
The number of CD34+ cells retrieved from PB by leukaphereses exceeds the number that can be harvested by multiple bone marrow aspirations under general anesthesia.
CD34 Binding (exceeds) of in bone marrow associated with anesthesia
2) Confidence 0.37 Published 1990 Journal Haematologica Section Abstract Doc Link 2190884 Disease Relevance 0.07 Pain Relevance 0.10
Immunohistochemical examination revealed positive reactivity to C-kit protein and CD34.
CD34 Binding (reactivity) of
3) Confidence 0.37 Published 2003 Journal J. Korean Med. Sci. Section Abstract Doc Link 14555833 Disease Relevance 0.58 Pain Relevance 0.08
After local excision, the pathologic diagnosis was atypical epithelioid hemangioma (central epithelioid cells bordered by immature vessels), with immunohistochemical positivity for CD31 and CD34 and negativity for epithelial membrane antigen.
CD34 Binding (positivity) of in vessels associated with hemangioma
4) Confidence 0.37 Published 2009 Journal Urology Section Abstract Doc Link 18342919 Disease Relevance 0.42 Pain Relevance 0.08
Although the number of circulating CD34+ cells between CAD patients and controls did not differ, consistent with the previously reported lack of association of CD34+ cell counts with carotid intima-media thickness [8], the transcriptome did show marked differences.
CD34 Binding (association) of associated with coronary artery disease
5) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.46 Pain Relevance 0
Rather than locally intervene with cytotoxic or cytostatic drugs, accelerated vascular healing with rapid establishment of a functional endothelial layer after vascular injury has been shown to assist in the prevention of neointimal proliferation and thrombus formation after stent placement.8,9 The Genous™ endothelial progenitor cell (EPC) capturing stent is coated with anti-human CD34+ antibodies that bind circulating EPCs from the peripheral blood to the stent surface.
CD34 Binding (bind) of in blood associated with vasculitis and thrombosis
6) Confidence 0.35 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2862178 Disease Relevance 0.57 Pain Relevance 0
Mononuclear cells were cultured for a minimum of five passages and characterized by cell-surface markers showing CD90+, CD105+, and CD34(-).
CD34 Binding (showing) of in Mononuclear cells
7) Confidence 0.35 Published 2009 Journal Rejuvenation Res Section Abstract Doc Link 19929258 Disease Relevance 1.23 Pain Relevance 0.27
In contrast, the periductal area was usually immunoreactive for alpha-SMA, but usually negative for CD34 and immunopositive for bcl-2, indicating a continuously progressive state of fibrosis, in which 'pre-existing'alpha-SMA immunoreactivity in the interlobular area may change in nature and lead to CD34-positive fibrosis or apoptosis.
CD34 Spec (may) Binding (negative) of associated with fibrosis and apoptosis
8) Confidence 0.34 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15189503 Disease Relevance 0.86 Pain Relevance 0.35
Isotype controls are not required because the gating strategy excludes cells that non-specifically bind anti-CD34.
CD34 Binding (bind) of
9) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.22 Pain Relevance 0
The diagnosis of schwannoma was supported by positive immunoreactivity for S-100 protein and collagen IV and absence of reactivity for keratin, muscle related antigens, and CD34 in both cases.
CD34 Binding (reactivity) of in muscle associated with neurilemmoma
10) Confidence 0.33 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16699318 Disease Relevance 1.19 Pain Relevance 0.16
Immunohistochemical studies revealed reactivity for CD34 and vimentin, but no staining for keratin, S-100, or alpha-smooth muscle actin, confirming a diagnosis of SFT.
CD34 Binding (reactivity) of in smooth muscle associated with solitary fibrous tumors
11) Confidence 0.32 Published 2004 Journal Surg. Today Section Abstract Doc Link 14714239 Disease Relevance 0.86 Pain Relevance 0.08
The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.
CD34 Binding (cytokeratin) of in smooth muscle
12) Confidence 0.31 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.83 Pain Relevance 0.07
These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen.
CD34 Binding (immunoreactive) of in smooth muscle
13) Confidence 0.31 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987150 Disease Relevance 0.83 Pain Relevance 0.12
GISTs can be recognized by their morphology (spindle cell or epithelioid), positivity for CD117 (about 95%) and to some extent their positivity for CD34 (about 70%) [1-3].
CD34 Binding (recognized) of
14) Confidence 0.31 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2567321 Disease Relevance 1.31 Pain Relevance 0
Immunohistochemical analysis performed on paraffin-embedded tissue sections was negative for pan-cytokeratin 7 and 20, epithelial membrane antigen (EMA), as well as a smooth muscle actin, desmin, CD34 and CD68.
CD34 Binding (actin) of in smooth muscle
15) Confidence 0.30 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843711 Disease Relevance 0.91 Pain Relevance 0
The tumor cells were positive for CD99 and bcl-2 in all cases and for CD56 in two cases and negative for CD34 and smooth muscle actin in all cases.
CD34 Binding (negative) of in smooth muscle associated with cancer
16) Confidence 0.28 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15105652 Disease Relevance 1.11 Pain Relevance 0.06
MSC have been defined as the cells having plastic-adherence when maintained under standard culture conditions, must have the ability of osteogenic, adipogenic and chondrogenic differentiation, must express CD73, CD90, and CD105, and must lack expression of hematopoietic lineage markers c-kit, CD14, CD34, CD 45, CD 11b, CD 29, CD79?
CD34 Neg (lack) Binding (lineage) of
17) Confidence 0.28 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.35 Pain Relevance 0
The whole marrow was mixed with the CD34+ selection cocktail and magnetic nanoparticles per manufacture?
CD34 Binding (mixed) of
18) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
For flow cytometry analysis the cells were detached with 0.05% trypsin/EDTA and washed with PBS. 1 × 105 cells per tube were blocked for 5 minutes with human AB serum (Sigma) and stained for 15 minutes incubated in an ice bath in the dark with direct PE or FITC conjugated mouse anti-human monoclonal antibodies (Becton Dickinson) recognizing CD11b, CD34, CD38, CD44, CD45, CD73, CD90, CD117 and HLA-DR.
CD34 Binding (recognizing) of in tube
19) Confidence 0.27 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0

General Comments

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