INT216834

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
astrocyte 1
oligodendrocytes 1
Lif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 2 97.52 Very High Very High Very High
cytokine 40 97.08 Very High Very High Very High
agonist 8 78.04 Quite High
dorsal root ganglion 1 68.24 Quite High
Inflammation 24 67.76 Quite High
adenocard 4 29.68 Quite Low
antagonist 19 5.00 Very Low Very Low Very Low
ischemia 14 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 2 97.48 Very High Very High Very High
Encephalitis 1 68.24 Quite High
Ganglion Cysts 1 68.24 Quite High
Injury 78 43.04 Quite Low
INFLAMMATION 26 40.40 Quite Low
Apoptosis 5 38.64 Quite Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Gliosis 24 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, LIF is released by astrocytes in response to ATP liberated from axons firing action potentials (see also Figure 2), and LIF promotes myelination by mature oligodendrocytes [10].
Localization (released) of LIF in oligodendrocytes associated with action potential
1) Confidence 0.34 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.23 Pain Relevance 0.36
Gliospheres were treated with physiologically relevant concentrations of EGF, LIF and TGFß1 either alone or in combination and Western blots were performed for GFAP, Zebrin II and glutamine synthetase (GS) as indices of astrocyte generation.
Localization (concentrations) of LIF in astrocyte
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.04
The levels of total STAT3, pSTAT3Ser and pSTAT3Tyr were elevated in the presence of LIF (Fig. 5A).
Localization (presence) of LIF
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0 Pain Relevance 0.06

General Comments

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