INT216839

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.27
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Anatomy Link Frequency
mast cell 4
neutrophils 2
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 384 99.98 Very High Very High Very High
Potency 106 99.96 Very High Very High Very High
Inflammation 71 99.04 Very High Very High Very High
cytokine 17 98.52 Very High Very High Very High
antagonist 95 96.08 Very High Very High Very High
agonist 267 93.60 High High
fibrosis 13 85.76 High High
Central nervous system 9 47.36 Quite Low
Kinase C 4 41.28 Quite Low
Opioid 9 40.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 63 99.04 Very High Very High Very High
Pulmonary Disease 11 98.88 Very High Very High Very High
Asthma 15 98.40 Very High Very High Very High
Adhesions 5 97.76 Very High Very High Very High
Targeted Disruption 12 91.60 High High
Cystic Fibrosis 12 85.76 High High
Disease 26 85.44 High High
Pressure Volume 2 Under Development 4 84.48 Quite High
Heart Rate Under Development 5 83.96 Quite High
Pneumonia 20 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NECA stimulated cAMP accumulation in both hA2BHEK 293 and native cells, whereas phospholipase C activation was observed in recombinant receptors and endogenous subtypes expressed in neutrophils but not in lymphocytes.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of A2B in neutrophils
1) Confidence 0.45 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.16 Pain Relevance 0.26
Replacement of the 6-amino group of NECA with the guanidino moiety determined a threefold enhancement in A2B AR activation potency (EC50?
Spec (determined) Positive_regulation (enhancement) of Positive_regulation (activation) of A2B associated with potency
2) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0 Pain Relevance 0.35
Activation of A2B AR subtype would moreover increase production of the anti-inflammatory cytokine IL-10 [50].
Positive_regulation (increase) of Positive_regulation (Activation) of A2B associated with inflammation and cytokine
3) Confidence 0.30 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.88 Pain Relevance 0.41
For example, activation of human A2B induces mast cell activation [65], whereas in mice this effect is mediated by A3 [66].
Positive_regulation (induces) of Positive_regulation (activation) of A2B in mast cell
4) Confidence 0.30 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.44 Pain Relevance 0.29
Moreover, adenosine stimulates production of interleukin (IL)-4 and IL-13 in mast cells via A2B AR activation [33].
Positive_regulation (stimulates) of Positive_regulation (activation) of A2B in mast cells associated with adenocard
5) Confidence 0.28 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.74 Pain Relevance 0.47
Fig. 4Schematic overview of the most important structural modifications of adenosine and nonadenosine derivatives for a potent and/or selective activation of the A2B AR



Positive_regulation (derivatives) of Positive_regulation (activation) of A2B associated with adenocard
6) Confidence 0.27 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.05 Pain Relevance 0.22

General Comments

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