INT216847

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.93
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2B) signal transducer activity (ADORA2B)
Anatomy Link Frequency
lymphocytes 1
colon 1
neutrophils 1
ADORA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 99.56 Very High Very High Very High
antagonist 120 99.00 Very High Very High Very High
agonist 70 98.36 Very High Very High Very High
Potency 10 98.00 Very High Very High Very High
adenocard 135 96.48 Very High Very High Very High
Inflammation 25 96.40 Very High Very High Very High
Hippocampus 5 89.20 High High
analgesia 5 71.40 Quite High
Opioid 5 71.00 Quite High
Analgesic 5 65.16 Quite High
Disease Link Frequency Relevance Heat
Pain 5 99.56 Very High Very High Very High
Cv Unclassified Under Development 5 99.20 Very High Very High Very High
Injury 5 98.76 Very High Very High Very High
Cancer 10 97.88 Very High Very High Very High
Asthma 25 97.56 Very High Very High Very High
INFLAMMATION 25 96.40 Very High Very High Very High
Breast Cancer 5 91.60 High High
Nociception 10 67.56 Quite High
Airway Remodeling 5 61.24 Quite High
Acute Erythroblastic Leukemia 5 56.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting of the A2B receptor protein to specific cells or tissues is crucial in order to understand their role in pathophysiological conditions.
Transcription (Targeting) of A2B receptor
1) Confidence 0.51 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.87 Pain Relevance 0.67
A2B messenger RNA has been found at low levels in all rat brain regions evaluated, aorta, stomach, testis, skeletal muscle, jejunum, kidney, heart, skin, spleen and liver whilst high levels have been detected in the proximal colon [6].
Transcription (found) of A2B in colon
2) Confidence 0.51 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.06 Pain Relevance 0.26
Despite the widespread distribution of A2B receptor mRNA, little information is available with regard to their function.
Transcription (distribution) of A2B receptor
3) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.31
Saturation experiments of [3H]MRE 2029-F20 binding in human neutrophils and lymphocytes detected a single high-affinity binding site with KD values of 2.4 and 2.7 nM, respectively, and Bmax values of 79 and 54 fmol/mg of protein, respectively, in agreement with real-time reverse transcription polymerase chain reaction studies showing the presence of A2B mRNA.
Transcription (presence) of A2B in lymphocytes
4) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.16
Saturation experiments of [3H]MRE 2029-F20 binding in human neutrophils and lymphocytes detected a single high-affinity binding site with KD values of 2.4 and 2.7 nM, respectively, and Bmax values of 79 and 54 fmol/mg of protein, respectively, in agreement with real-time reverse transcription polymerase chain reaction studies showing the presence of A2B mRNA.
Transcription (presence) of A2B in neutrophils
5) Confidence 0.13 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.16

General Comments

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