INT216848

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.59
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TCIRG1) plasma membrane (TCIRG1) transmembrane transport (TCIRG1)
TCIRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 338 100.00 Very High Very High Very High
agonist 268 100.00 Very High Very High Very High
antagonist 104 100.00 Very High Very High Very High
Inflammation 46 95.58 Very High Very High Very High
Potency 108 88.52 High High
amygdala 57 82.76 Quite High
Pain 11 40.64 Quite Low
Neurotransmitter 4 40.00 Quite Low
Central nervous system 4 39.28 Quite Low
Hippocampus 3 17.52 Low Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 99.68 Very High Very High Very High
Osteopetrosis 72 99.28 Very High Very High Very High
INFLAMMATION 50 95.58 Very High Very High Very High
Hypoxia 6 95.04 Very High Very High Very High
Depression 3 85.44 High High
Disease 27 70.00 Quite High
Reprotox - General 1 8 68.68 Quite High
Dyslipidemia /

Combined Dyslipidemia

4 68.64 Quite High
Cancer 13 67.64 Quite High
Metabolic Syndrome 8 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous mutations in the genes encoding the a3 subunit of V-ATPase (TCIRG1) and the CLCN-7 produce severe malignant osteopetrosis phenotypes in both humans and mice [37-40].
Gene_expression (produce) of TCIRG1 associated with osteopetrosis and malignant neoplastic disease
1) Confidence 0.52 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2654865 Disease Relevance 0.73 Pain Relevance 0
Binding to membranes expressing rat and human A1 and A3 adenosine receptors was not significant, and binding in membranes of HEK 293 cells expressing human A2A receptors was of low affinity (KD > 50 nM).
Gene_expression (expressing) of A3 associated with adenocard
2) Confidence 0.16 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0 Pain Relevance 0.32
In hypoxic, ischaemic or inflammatory conditions, the intracellular levels of adenosine can grow to very high micromolar concentrations and, thanks to specific transports across cell membranes, the endogenous nucleoside can activate the low-affinity A2B and A3 AR subtypes.
Gene_expression (subtypes) of A3 associated with adenocard, inflammation and hypoxia
3) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.19 Pain Relevance 0.35
2.1; Ki A3/EC50 A2B?
Gene_expression (2.1) of A3
4) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.45 Pain Relevance 0.13
2.1; Ki A3/EC50 A2B?
Gene_expression (/) of A3
5) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.45 Pain Relevance 0.13
299 nM), although the selectivity profile was not so satisfactory (Ki values at A1, A2A, A3 ARs of 148, 45, 232 nM, respectively).
Gene_expression (values) of A3
6) Confidence 0.05 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.07 Pain Relevance 0.38
Whilst for A1, A2A and A3 adenosine subtypes good agonists and antagonists have been synthesized allowing a plethora of binding and functional studies, no high-affinity analogues have been identified for the A2B receptors until a couple of years ago, and neither high-affinity nor selective antagonists had been introduced until 2001 [3, 7, 8].
Neg (no) Gene_expression (synthesized) of A3 associated with adenocard, antagonist and agonist
7) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096665 Disease Relevance 0.42 Pain Relevance 0.57
made the unrewarded stimulus an inhibitory predictor according to the schemes of Fig. 1, A3 and B3 (note that background reward did not continue during the unrewarded stimulus).
Gene_expression (schemes) of A3
8) Confidence 0.05 Published 2010 Journal Journal of Neurophysiology Section Body Doc Link PMC2887637 Disease Relevance 0.14 Pain Relevance 0.07

General Comments

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