INT21685

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Context Info
Confidence 0.66
First Reported 1980
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 115
Total Number 118
Disease Relevance 85.60
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 14
AtT-20 3
heart 3
eye 3
retina 2
ras (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 278 99.90 Very High Very High Very High
Inflammatory stimuli 1 99.68 Very High Very High Very High
tetrodotoxin 33 99.20 Very High Very High Very High
cytokine 51 98.74 Very High Very High Very High
headache 26 98.54 Very High Very High Very High
fibrosis 84 98.28 Very High Very High Very High
imagery 118 98.08 Very High Very High Very High
palliative 29 97.96 Very High Very High Very High
Kinase C 111 97.80 Very High Very High Very High
Potency 16 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Canker Sores 140 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 10 100.00 Very High Very High Very High
Vasculitis 25 99.90 Very High Very High Very High
Nerve Sheath Neoplasms 110 99.86 Very High Very High Very High
Cancer 2883 99.84 Very High Very High Very High
Colon Cancer 1423 99.84 Very High Very High Very High
Nicotine Addiction 158 99.84 Very High Very High Very High
Frailty 14 99.84 Very High Very High Very High
Infection 165 99.76 Very High Very High Very High
INFLAMMATION 299 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, cigarette smokers for periods >5 years also had one-third the odds of RAS (OR = 0.34) than those who smoked for ?
Gene_expression (odds) of RAS associated with nicotine addiction and canker sores
1) Confidence 0.66 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 1.95 Pain Relevance 0
Moreover, Lu and co-workers elegantly demonstrated that ATF3 is capable of suppressing a Ras-mediated tumorigenicity of murine fibroblasts (ATF3-/- versus ATF3+/+ fibroblasts) in an in vitro, as well as in an in vivo model, hence supporting our hypothesis of a tumor suppressive role.
Gene_expression (suppressing) of Ras in fibroblasts associated with cancer
2) Confidence 0.65 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.06 Pain Relevance 0
The rate of inactivation of the TTX-resistant current in control cells was slower, than that of the TTX-sensitive current in either control or ras-transfected AtT-20 cells.
Gene_expression (transfected) of ras in AtT-20 associated with tetrodotoxin
3) Confidence 0.65 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2191273 Disease Relevance 0.08 Pain Relevance 0.93
Therefore, it is possible that higher mean age of smokers compared to non-smokers was responsible for the significantly lower prevalence of RAS in smokers reported in some studies that used only bivariate analysis.
Gene_expression (prevalence) of RAS associated with nicotine addiction and canker sores
4) Confidence 0.58 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.00 Pain Relevance 0.04
Another potential cause of reduced insulin sensitivity through RAS activation may be a result of vasoconstrictive effects, thereby reducing blood flow to skeletal muscle (Furuhashi et al 2003).
Gene_expression (activation) of RAS in skeletal muscle
5) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.05 Pain Relevance 0.03
A logical question raised by this clinical data is whether RAS blockade would be an appropriate treatment for patients with metabolic syndrome.
Spec (whether) Gene_expression (blockade) of RAS associated with metabolic syndrome
6) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.69 Pain Relevance 0.04
In addition, there are also important effects of the RAS on all steps in the atherosclerotic process, including endothelial dysfunction, inflammation, thrombosis and plaque stabilization, which we have not discussed in this review.
Gene_expression (effects) of RAS in plaque associated with inflammation, atherosclerosis and thrombosis
7) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.85 Pain Relevance 0.05
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current.
Gene_expression (Transfection) of ras in AtT-20 associated with tetrodotoxin
8) Confidence 0.56 Published 1990 Journal Pflugers Arch. Section Title Doc Link 2191273 Disease Relevance 0.09 Pain Relevance 0.90
AtT-20 cells transfected with the c-Ha-ras gene expressed only a TTX-sensitive current.
Gene_expression (transfected) of ras in AtT-20 associated with tetrodotoxin
9) Confidence 0.49 Published 1990 Journal Pflugers Arch. Section Abstract Doc Link 2191273 Disease Relevance 0.10 Pain Relevance 0.97
A propensity score for RAS blockade was calculated for each subject using several factors: age, sex, serum creatinine, hypertension, heart disease, congestive heart failure, stroke, diabetes, and exposure to cardiovascular medications.
Gene_expression (blockade) of RAS in heart
10) Confidence 0.48 Published 2010 Journal Can J Anaesth Section Body Doc Link 20524103 Disease Relevance 0 Pain Relevance 0
Logistic regression analysis identified predictors of RAS blockade: hypertension, stroke, congestive heart failure, diabetes, and heart disease.
Gene_expression (blockade) of RAS in heart
11) Confidence 0.48 Published 2010 Journal Can J Anaesth Section Body Doc Link 20524103 Disease Relevance 0 Pain Relevance 0
The long-lasting effect of CVS experienced in prepubertal life appears to produce ASR changes similar to those seen in patients with posttraumatic stress disorder (PTSD).
Gene_expression (produce) of ASR associated with stress and post-traumatic stress disorder
12) Confidence 0.46 Published 2002 Journal Physiol. Behav. Section Abstract Doc Link 11890971 Disease Relevance 2.03 Pain Relevance 0
RAS expression in the liver and colorectal metastases
Gene_expression (expression) of RAS in liver associated with metastasis
13) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.55 Pain Relevance 0
However, the ontogeny of RAS expression during CRC liver metastases progression has not been described, nor have the effects of captopril treatment on RAS expression in tumors been documented.
Gene_expression (expression) of RAS in liver associated with cancer, colon cancer and metastasis
14) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.52 Pain Relevance 0
Several components of the RAS are expressed in primary CRC and we have shown previously that blockade of the RAS decreased tumor growth in a mouse model of CRC liver metastases [8,19].
Gene_expression (expressed) of RAS in liver associated with cancer, colon cancer and metastasis
15) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.38 Pain Relevance 0
Key components of the RAS, namely angiotensinogen, ACE, ACE2, AT1R, AT2R, and the MasR were expressed in the sham liver, tumor-induced liver, and in CRC liver metastases (tumors) at all stages examined.
Gene_expression (expressed) of RAS in liver associated with cancer, colon cancer and metastasis
16) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.02 Pain Relevance 0
These cancer cells are derived from transformed epithelial cells of the colon and the difference in RAS expression of these cells compared to the tumor-bearing and naïve liver most likely represents a combination of differences due to transformation and tissue origin (colon versus liver).
Gene_expression (expression) of RAS in liver associated with cancer
17) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 2.00 Pain Relevance 0
However, the ontogeny of RAS expression during CRC liver metastases progression has not been described, nor have the effects of captopril treatment on RAS expression in tumors been documented.
Gene_expression (expression) of RAS in liver associated with cancer, colon cancer and metastasis
18) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.52 Pain Relevance 0
The overexpression of MYC (as a transgene) and other oncogenes (e.g., RAS, T antigen) in murine hepatocytes results in HCC (Sandgren et al. 1989).
Gene_expression (overexpression) of RAS in hepatocytes associated with hepatocellular cancer
19) Confidence 0.44 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.16 Pain Relevance 0
Captopril treatment alters expression of the RAS in tumors
Gene_expression (expression) of RAS associated with cancer
20) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.34 Pain Relevance 0

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